dry eye syndromes

Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

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Study Counts

Type	Study_count
Total_Studies	543
interventional	479
Observational	59
Registry	5

Studies over Time by Start Date

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Interventional Trials

Intervention Type

intervention_type	Study_Count
Drug	191
Drug|placebo	86
Device	83
Other	53
Drug|Other	9
Device|Procedure	8
Procedure	8
Dietary Supplement|placebo	6
Device|Other	5
Biological	4
Device|Drug	4
Biological|placebo	3
Diagnostic Test	2
Dietary Supplement	2
Dietary Supplement|Other	2
Other|Procedure	2
Behavioral	1
Behavioral|Drug|Procedure	1
Biological|Drug	1
Biological|Drug|Other	1
Combination Product|Device	1
Device|Dietary Supplement|Other	1
Device|placebo	1
Diagnostic Test|Drug	1
Dietary Supplement|Drug|Other	1
Dietary Supplement|Drug|placebo	1
Drug|Procedure	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country	Study_Count
United States	227
NA	66
Korea, Republic of	22
Austria	19
Japan	16
China	13
Singapore	10
Canada	9
France	9
Mexico	9
Israel	7
United Kingdom	7
Brazil	6
Spain	5
Australia	4
Italy	4
Finland	3
India	3
Taiwan	3
Thailand	3
Argentina	2
Chile	2
Denmark	2
Egypt	2
France|Spain	2
Germany	2
Netherlands	2
Australia|Belgium|France|Germany|Italy|Russian Federation|Spain|United Kingdom	1
Australia|Canada	1
Austria|Germany|Hungary	1
Cambodia	1
China|Singapore	1
Croatia	1
Czechia|France|Italy|Poland|Russian Federation|Spain|Turkey	1
Estonia|Germany|Italy|Portugal|Slovakia|Spain	1
Estonia|Spain	1
France|United Kingdom	1
Greece	1
Japan|Korea, Republic of	1
Norway	1
Sweden	1
Switzerland	1
Tunisia	1
Turkey	1
United States|Australia	1
United States|Canada	1
United States|Spain|United Kingdom	1

Sites per Study

Site_count	Study_Count
1	348
2	27
3	25
4	6
5	12
6	8
7	3
8	2
9	4
10	3
11	5
12	3
13	3
14	2
15	1
16	2
17	1
19	1
20	1
22	2
23	2
26	1
27	3
28	2
31	1
34	1
35	1
40	1
41	1
45	2
60	2
62	1
63	1
81	1

Phase

Phase	Study_Count
N/A	175
Phase 2	93
Phase 4	81
Phase 3	80
Phase 1	20
Phase 2/Phase 3	14
Phase 1/Phase 2	12
Early Phase 1	4

Number of Arms

Number_of_Arms	Count_of_Studies
1	77
2	257
3	73
4	35
5	2
6	4
8	2
NA	29

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	7.00	2.0000	5.00000	27.0000	9.0000	23.0000	18.0000	5.000
1st Qu.	16.75	25.0000	24.00000	60.0000	74.0000	62.7500	181.5000	30.000
Median	30.00	47.5000	32.00000	80.5000	148.5000	179.5000	329.0000	50.000
Mean	29.75	216.3333	38.52632	107.8333	163.8667	197.1429	391.9867	78.725
3rd Qu.	43.00	88.7500	46.00000	123.0000	205.5000	297.7500	594.0000	73.500
Max.	52.00	25875.0000	100.00000	327.0000	765.0000	480.0000	1936.0000	941.000

Trial Group Type

group_type	Group_Count
Experimental	499
Active Comparator	257
Placebo Comparator	180
Other	34
NA	29
No Intervention	16
Sham Comparator	14

Intervention Model

intervention_model	Study_Count
Parallel Assignment	327
Single Group Assignment	98
Crossover Assignment	46
NA	6
Factorial Assignment	2

Primary Purpose

primary_purpose	Study_Count
Treatment	400
NA	21
Basic Science	16
Supportive Care	14
Other	9
Diagnostic	8
Prevention	5
Screening	3
Device Feasibility	2
Health Services Research	1

Observational Studies

Studies by Country

Country	Study_Count
United States	24
Germany	5
Canada	4
Singapore	4
France	3
Korea, Republic of	3
NA	3
Taiwan	3
Austria	2
China	2
Croatia	1
Israel	1
Norway	1
Portugal	1
Russian Federation	1
United States|France|Germany|Spain|United Kingdom	1

Sites per Study

Site_count	Study_Count
1	47
2	3
3	1
5	1
6	2
8	3
10	1
17	1

Enrollment Metrics

Measure	Observational
Min	1.0000
1st Qu	40.0000
Median	90.0000
Mean	311.5763
3rd Qu	241.5000
Max	5000.0000

Observation Model

observational_model	Study_Count
Cohort	20
Case-Only	13
Case-Control	11
Case Control	9
NA	3
Case-Crossover	1
Ecologic or Community	1
Other	1

Time Perspective

time_perspective	Study_Count
Prospective	38
Cross-Sectional	15
Retrospective	5
NA	1

Registries

Studies by Country

Country	Study_Count
China	3
Taiwan	1
United Kingdom	1

Sites per Study

Site_count	Study_Count
1	4
2	1

Enrollment Metrics

Measure	Registries
Min	35
1st Qu	50
Median	300
Mean	304
3rd Qu	500
Max	635

Registry Model

observational_model	Study_Count
Case-Control	2
Cohort	2
Case Control	1

Time Perspective

time_perspective	Study_Count
Prospective	5

Follow-up

target_duration	Study_Count
1 Day	2
1 Month	1
3 Years	1
8 Weeks	1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT04457999	Clinical Outcome of Lipiflow Treatment Prior to Cataract Surgery in Dry Eye Patients	https://ClinicalTrials.gov/show/NCT04457999	Recruiting	Samsung Medical Center	2020-07-02
NCT04457648	Manuka Honey Eye Drops VS Conventional Treatment of Meibomian Gland Dysfunction Related Dry Eye Disease	https://ClinicalTrials.gov/show/NCT04457648	Completed	Chinese University of Hong Kong	2020-06-01
NCT04393441	Efficacy and Safety of a New Artificial Tear Formulation Compared With Systane Ultra Multidose in Participants With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT04393441	Recruiting	Allergan	2020-11-27
NCT03937882	Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome: ARISE-3	https://ClinicalTrials.gov/show/NCT03937882	Recruiting	ReGenTree, LLC	2020-08-31
NCT03396913	Effectiveness of Intense Pulsed Light for Improving Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT03396913	Completed	Lumenis Ltd.	2019-08-15
NCT03380624	Tear Lipid Layer Thickness With Emollient Eye Drops	https://ClinicalTrials.gov/show/NCT03380624	Completed	Ohio State University	2018-06-30
NCT03368404	A Study to Evaluate the Performance and Safety of CBL-102 Versus Vismed® Multi Eye Drops in the Management of Dry Eye	https://ClinicalTrials.gov/show/NCT03368404	Active, not recruiting	Laboratoire Chauvin	2020-03-31
NCT03821415	Effects of RP101 in Post-menopausal Women With Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT03821415	Completed	Redwood Pharma AB	2019-11-18
NCT03334539	A Study to Assess Efficacy of HL036 in Subjects With Dry Eyes	https://ClinicalTrials.gov/show/NCT03334539	Completed	HanAll BioPharma Co., Ltd.	2018-05-31
NCT03333057	Perfluorohexyloctane (NOV03) for the Treatment of Signs and Symptoms of Dry Eye Disease (DED)	https://ClinicalTrials.gov/show/NCT03333057	Completed	Novaliq GmbH	2018-05-18
NCT03332342	Closed Eye Neutrophils in Dry Eye Disease	https://ClinicalTrials.gov/show/NCT03332342	Completed	University of Alabama at Birmingham	2018-12-12
NCT03325673	Clinical Trial to Evaluate the Symptoms in Symptomatic Contact Lens Wearers Following Application of Intranasal Tear Neurostimulator Versus Control	https://ClinicalTrials.gov/show/NCT03325673	Completed	Allergan	2018-11-29
NCT03319420	Evaluate the Efficacy and Safety of LO2A Eye Drops for Symptomatic Improvement of Dry Eye in Patients With Sjögren’s Syndrome	https://ClinicalTrials.gov/show/NCT03319420	Recruiting	Ocuwize LTD	2020-09-30
NCT03318874	Optimization of the Treatment of Dry Eye Disease Caused by Meibomian Gland Dysfunction	https://ClinicalTrials.gov/show/NCT03318874	Active, not recruiting	Oslo University Hospital	2020-04-15
NCT03302273	Corneal Epithelial Stem Cells and Dry Eye Disease	https://ClinicalTrials.gov/show/NCT03302273	Enrolling by invitation	Panhandle Eye Group, LLP	2021-02-01
NCT03292809	CyclASol for the Treatment of Signs and Symptoms of Dry Eye Disease (DED)	https://ClinicalTrials.gov/show/NCT03292809	Completed	Novaliq GmbH	2018-05-22
NCT03287635	Clinical Efficacy of H.P. Acthar Gel 80 U/ml to Improve the Signs and Symptoms in Subjects With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT03287635	Recruiting	Toyos Clinic	2020-05-31
NCT03265652	IPL and MGX Versus MGX Alone in the Treatment of Dry Eye Disease Secondary to MGD	https://ClinicalTrials.gov/show/NCT03265652	Completed	Lumenis Ltd.	2019-04-18
NCT03265327	Effect of an Oral Supplement Containing Omega-3 and Omega-6 on Dry Eye Symptoms	https://ClinicalTrials.gov/show/NCT03265327	Completed	Nature’s Way Canada	2018-06-27
NCT03228784	The Effect of Ablation Depth on Dry Eye After LASIK Treatment of Myopia	https://ClinicalTrials.gov/show/NCT03228784	Completed	Minia University	2014-05-01
NCT03226769	Safety and Efficacy of TrueTearâ„¢ for the Treatment of Meibomian Gland Disease	https://ClinicalTrials.gov/show/NCT03226769	Completed	Allergan	2017-10-29
NCT03226444	Lacripepâ„¢ in Subjects With Dry Eye Associated With Primary Sjögren’s Syndrome	https://ClinicalTrials.gov/show/NCT03226444	Completed	TearSolutions, Inc.	2019-12-27
NCT03216096	Assessing Safety and Efficacy of DE-089 Ophthalmic Solution in Patients With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT03216096	Completed	Santen Pharmaceutical Co., Ltd.	2018-02-01
NCT03211351	Effects of Two Tear Substitutes in Patients With Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT03211351	Completed	Huaxia Eye Hospital Group	2017-12-01
NCT03208673	Optive Brand For Day And Night Dry Eye Management	https://ClinicalTrials.gov/show/NCT03208673	Completed	Allergan	2017-09-06
NCT03204903	Laser Acupuncture for Dry Eye	https://ClinicalTrials.gov/show/NCT03204903	Recruiting	Chang Gung Memorial Hospital	2019-07-31
NCT03194698	Efficacy of IPL Treatment of Dry Eye and Ocular Rosacea	https://ClinicalTrials.gov/show/NCT03194698	Completed	Mayo Clinic	2018-12-06
NCT03183089	Comparative Study of Rohto Dry-Aid® and Systane® Ultra in Patients With Dry Eye	https://ClinicalTrials.gov/show/NCT03183089	Completed	The Mentholatum Company	2016-01-04
NCT03162497	Effect of Topical Azithromycin on Tear Film Thickness in Patients With Meibomian Gland Dysfunction	https://ClinicalTrials.gov/show/NCT03162497	Recruiting	Medical University of Vienna	2020-07-31
NCT03161080	Effect of Single Instillation of Three Different Topical Lubricants on Tear Film Thickness in Patients With Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT03161080	Completed	Medical University of Vienna	2017-05-12
NCT03141931	The Effects of Dietary Supplementation With Omega-3 Fatty Acids on Symptoms of Dry Eye	https://ClinicalTrials.gov/show/NCT03141931	Completed	The University of New South Wales	2018-10-19
NCT03116776	Walnut Shell Glasses Moxibustion for Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT03116776	Recruiting	Guang’anmen Hospital of China Academy of Chinese Medical Sciences	2018-07-30
NCT03108664	HELIX, a Double-masked Study of SYL1001 in Patients With Moderate to Severe Dry Eye Disease (DED)	https://ClinicalTrials.gov/show/NCT03108664	Completed	Sylentis, S.A.	2018-10-16
NCT03097614	Dry Eye Symptom Relief Assessment With Use of TrueTear in a Controlled Adverse Environment	https://ClinicalTrials.gov/show/NCT03097614	Completed	Oculeve, Inc.	2017-06-26
NCT03088605	Safety and Efficacy of TOP1630 for Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT03088605	Completed	Topivert Pharma Ltd	2017-06-15
NCT03085290	Allogeneic Versus Autologous Serum Eye Drops	https://ClinicalTrials.gov/show/NCT03085290	Completed	Sanquin Research & Blood Bank Divisions	2018-10-08
NCT03074344	Cross-linked Hyaluronic Acid and Coenzyme Q10 in the Treatment of Dry Eye	https://ClinicalTrials.gov/show/NCT03074344	Completed	Azienda Ospedaliera Universitaria Policlinico “G. Martino”	2016-07-31
NCT03066219	Safety and Efficacy of BRM421 for Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT03066219	Completed	BRIM Biotechnology Inc.	2017-05-20
NCT03052140	Lamelleye vs Comparator for the Treatment of Dry Eye Disease	https://ClinicalTrials.gov/show/NCT03052140	Completed	Glasgow Caledonian University	2017-08-09
NCT04454983	Lipiflow vs iLux Patient Acceptance and Comfort Study	https://ClinicalTrials.gov/show/NCT04454983	Completed	Epstein, Arthur B., OD, FAAO	2020-02-29
NCT03019627	An 8-week Study to Evaluate Safety and Efficacy of NGF Eye Drops Solution Versus Vehicle in Patients With Dry Eye	https://ClinicalTrials.gov/show/NCT03019627	Completed	Dompé Farmaceutici S.p.A	2017-08-31
NCT03012698	Pilot Study for Testing Safety of Repetitive Magnetic Stimulation for Treatment of Dry Eye	https://ClinicalTrials.gov/show/NCT03012698	Completed	Epitech Mag Ltd.	2019-06-17
NCT02986750	Influence of Three Different Formulations of Lachrymal Substitutes on Tear Film Thickness and Other Signs and Symptoms in Patients With Moderate to Severe Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT02986750	Completed	Medical University of Vienna	2017-03-23
NCT02980913	Difference in the Frequency of Use of Lachrymal Substitutes in Patients With Moderate to Severe Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT02980913	Completed	Medical University of Vienna	2016-05-17
NCT02980224	Study of the Safety and Efficacy of OmegaD Softgels in the Treatment of Dry Eye Disease	https://ClinicalTrials.gov/show/NCT02980224	Completed	OmegaD LLC	2017-02-28
NCT02975102	A Study to Evaluate the Performance and Safety of CBL-101 Versus Vismed® Multi Eye Drops in the Management of Dry Eye	https://ClinicalTrials.gov/show/NCT02975102	Completed	Laboratoire Chauvin	2019-09-17
NCT02974907	Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome : ARISE-2	https://ClinicalTrials.gov/show/NCT02974907	Completed	ReGenTree, LLC	2017-09-30
NCT02956083	The Effect of Tear Supplements on Contact Lens Comfort	https://ClinicalTrials.gov/show/NCT02956083	Completed	University of the Incarnate Word	2015-07-31
NCT02951910	A Study of the Effect of Zinc-Hyaluronate on Ocular Surface Sensations in Patients With Dry Eye	https://ClinicalTrials.gov/show/NCT02951910	Completed	Semmelweis University	2016-08-31
NCT02917512	Efficacy and Safety Study of HU00701/HU007 Eye Drops in Patients With Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT02917512	Completed	Huons Co., Ltd.	2016-12-31
NCT02910713	Evaluation of Dry Eye Symptoms in CAE With Application of Intranasal Neurostimulation	https://ClinicalTrials.gov/show/NCT02910713	Completed	Allergan	2016-10-31
NCT02908282	Topical Omega-3 Fatty Acids (REMOGEN® OMEGA) in the Treatment of Dry Eye	https://ClinicalTrials.gov/show/NCT02908282	Completed	TRB Chemedica AG	2018-07-31
NCT02871440	A Two Comparator, Controlled Phase 3 Study in Patients With and Without Evaporative Dry Eye	https://ClinicalTrials.gov/show/NCT02871440	Completed	The University of New South Wales	2017-09-18
NCT02848222	Pilot Study for Investigating the Effect of the Bruder Eye Hydrating Compress on Contact Lens Discomfort in Contact Lens Wearers	https://ClinicalTrials.gov/show/NCT02848222	Completed	University of Alabama at Birmingham	2017-12-31
NCT02845674	An Open-Label Extension of a Phase 3 Study of OTX-101 in the Treatment of Keratoconjunctivitis Sicca	https://ClinicalTrials.gov/show/NCT02845674	Completed	Sun Pharma Global FZE	2017-08-15
NCT02819284	Safety and Efficacy of KPI-121 Compared to Placebo in Subjects With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT02819284	Completed	Kala Pharmaceuticals, Inc.	2017-09-30
NCT02813265	Safety and Efficacy of KPI-121 in Subjects With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT02813265	Completed	Kala Pharmaceuticals, Inc.	2017-10-31
NCT02802150	The Effect of Oral Zanthoxylum Schinifolium Seed Oil in Individuals With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT02802150	Completed	Chonbuk National University Hospital	2015-07-31
NCT02776670	Clinical Outcomes Following Treatment With SYSTANE® BALANCE	https://ClinicalTrials.gov/show/NCT02776670	Completed	Alcon Research	2017-11-22
NCT02764814	In Vivo Confocal Microscopic Analysis of Corneal Nerve Changes After ProKera Slim® for Dry Eye	https://ClinicalTrials.gov/show/NCT02764814	Completed	Tissue Tech Inc.	2016-09-30
NCT02758327	Evaluation of Tear Osmolarity Over Time With Sustained Use of Thera Tears Lubricating Drops	https://ClinicalTrials.gov/show/NCT02758327	Completed	Koffler Vision Group	2016-03-31
NCT02752763	Comparison of Autologous Serum Versus Preservative Free Artificial Tear	https://ClinicalTrials.gov/show/NCT02752763	Completed	NiÄŸde State Hospital	2016-03-31
NCT02701764	Can Pregabalin Reduce the Frequency and Severity of Dry Eye Symptoms After Laser-assisted in Situ Keratomileusis?	https://ClinicalTrials.gov/show/NCT02701764	Completed	University of Miami	2018-12-01
NCT02688556	Phase 3 Study of OTX-101 in the Treatment of Keratoconjunctivitis Sicca	https://ClinicalTrials.gov/show/NCT02688556	Completed	Sun Pharma Global FZE	2016-11-30
NCT02683382	Effects of a Moisturizing Product on Dry Eye and Skin	https://ClinicalTrials.gov/show/NCT02683382	Completed	Aromtech Ltd.	2016-06-30
NCT02680158	A Study to Evaluate the Safety and Effectiveness of Oculeve Intranasal Lacrimal Neurostimulator in Participants With Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT02680158	Completed	Oculeve, Inc.	2016-03-31
NCT02665234	A Safety and Efficacy Study of Tavilermide (MIM-D3) Ophthalmic Solution for the Treatment of Dry Eye Disease	https://ClinicalTrials.gov/show/NCT02665234	Completed	Mimetogen Pharmaceuticals USA, Inc.	2017-02-28
NCT02634853	A Safety and Efficacy Study of Tavilermide (MIM-D3) Ophthalmic Solution for the Treatment of Dry Eye	https://ClinicalTrials.gov/show/NCT02634853	Completed	Mimetogen Pharmaceuticals USA, Inc.	2017-02-28
NCT02621593	Feasibility of IPL for Reducing Dry Eye Symptoms Caused by MGD	https://ClinicalTrials.gov/show/NCT02621593	Completed	Lumenis Ltd.	2017-01-31
NCT02617667	CyclASol for the Treatment of Moderate to Severe Dry-eye Disease (DED)	https://ClinicalTrials.gov/show/NCT02617667	Completed	Novaliq GmbH	2016-07-31
NCT02608489	Clinical Effects and Safety of 3% Diquafosol After Cataract Surgery	https://ClinicalTrials.gov/show/NCT02608489	Completed	Soonchunhyang University Hospital	2015-01-31
NCT02597803	Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome: ARISE-1	https://ClinicalTrials.gov/show/NCT02597803	Completed	ReGenTree, LLC	2016-06-30
NCT02585648	Added Benefits of Lachrymal Substitute Gel During the Night in Patients With Moderate to Severe Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT02585648	Completed	Medical University of Vienna	2016-05-31
NCT02585453	Influence of Lachrymal Substitute Gels on Tear Film Thickness in Patients With Moderate to Severe Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT02585453	Completed	Medical University of Vienna	2015-09-30
NCT03404115	A Multi-Center, Randomized, Double Masked, Parallel-Group, Vehicle-Controlled, Clinical Study to Assess the Safety and Efficacy of Reproxalap Ophthalmic Solution in Subjects With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT03404115	Completed	Aldeyra Therapeutics, Inc.	2018-07-11
NCT02554981	Evaluation of Maintaining Visual Performance in Participants Who Engage in Electronic Visual Tasking While Using Restasis®	https://ClinicalTrials.gov/show/NCT02554981	Completed	Allergan	2016-03-24
NCT02554084	Optical Coherence Tomography of Tear Film Dynamics In-Vivo	https://ClinicalTrials.gov/show/NCT02554084	Completed	University of Rochester	2017-09-30
NCT02553772	A Safety and Efficacy Study of a New Eye Drop Formulation in Patients With Dry Eye Disease.	https://ClinicalTrials.gov/show/NCT02553772	Completed	Allergan	2016-09-09
NCT02526290	Six Month Study to Evaluate the Safety and Effectiveness of the Intranasal Lacrimal Neurostimulator	https://ClinicalTrials.gov/show/NCT02526290	Completed	Oculeve, Inc.	2016-04-30
NCT02510235	Tolerability, Safety and Efficacy of Lubricin Eye Drops vs Sodium Hyaluronate Eye Drops in Subjects With Mod. Dry Eye	https://ClinicalTrials.gov/show/NCT02510235	Completed	Dompé Farmaceutici S.p.A	2015-05-31
NCT02507934	Tolerability, Safety and Efficacy of Lubricin (150 µg/ml) Eye Drops Versus Sodium Hyaluronate (HA) 0.18% Eye Drops in Patients With Moderate Dry Eye (DE)	https://ClinicalTrials.gov/show/NCT02507934	Completed	Dompé Farmaceutici S.p.A	2015-08-31
NCT02503189	A Phase III Study of KCT-0809 in Dry Eye Patients With Sjögren’s Syndrome	https://ClinicalTrials.gov/show/NCT02503189	Completed	Kissei Pharmaceutical Co., Ltd.	2017-01-31
NCT02503163	A Long-term Study of KCT-0809 in Dry Eye Patients With Sjögren’s Syndrome	https://ClinicalTrials.gov/show/NCT02503163	Completed	Kissei Pharmaceutical Co., Ltd.	2017-10-19
NCT02492412	Efficacy and Safety of HE10 for Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT02492412	Completed	Huons Co., Ltd.	2014-07-31
NCT02470429	Evaluation of Clinical Outcomes After the Use of SYSTANE® HYDRATION	https://ClinicalTrials.gov/show/NCT02470429	Completed	Alcon Research	2016-05-26
NCT02468700	OTX-14-006: A Phase 2 Study Evaluating the Safety and Efficacy of OTX-DP for the Treatment of Dry Eye	https://ClinicalTrials.gov/show/NCT02468700	Completed	Ocular Therapeutix, Inc.	2015-08-31
NCT02461719	Efficacy and Safety Study of TJCS for Treatment of Moderate to Severe Dry Eye Syndromes	https://ClinicalTrials.gov/show/NCT02461719	Completed	Taejoon Pharmaceutical Co., Ltd.	2014-09-30
NCT02455999	Dose-finding Study to Assess the Safety and Effect of SYL1001 in Patients With Ocular Pain	https://ClinicalTrials.gov/show/NCT02455999	Completed	Sylentis, S.A.	2016-03-31
NCT02455050	A Study to Compare a New Eye Drop Formulation With Systane® Gel Drops and Genteal® Lubricant Gel Drops for Moderate to Severe Dry Eye Relief	https://ClinicalTrials.gov/show/NCT02455050	Completed	Allergan	2015-08-31
NCT02446015	Clinical Evaluation Following Use of SYSTANE® ULTRA in the Management of Dry Eye	https://ClinicalTrials.gov/show/NCT02446015	Completed	Alcon Research	2016-06-21
NCT02435914	Safety, Efficacy, Tolerability and Pharmacokinetics of AGN-223575 Ophthalmic Suspension in Patients With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT02435914	Completed	Allergan	2016-01-31
NCT02420834	Dry Eye Treatment With Artificial Tears	https://ClinicalTrials.gov/show/NCT02420834	Completed	Aston University	2019-01-31
NCT02420730	Safety, Tolerability and Systemic Pharmacokinetics of AGN-232411 in Healthy Participants and Participants With Dry Eye	https://ClinicalTrials.gov/show/NCT02420730	Completed	Allergan	2016-03-31
NCT02417116	Tear Osmolarity Clinical Utility in Dry Eye Disease	https://ClinicalTrials.gov/show/NCT02417116	Completed	Aston University	2019-01-31
NCT02403219	Paralysis of the Orbicularis Muscle of the Eye in the Treatment for Dry Eye	https://ClinicalTrials.gov/show/NCT02403219	Completed	Instituto de Oftalmología Fundación Conde de Valenciana	2014-02-28
NCT02385292	Multicenter Trial Evaluating Quality of Tears Produced by Nasal Neurostimulation	https://ClinicalTrials.gov/show/NCT02385292	Completed	Oculeve, Inc.	2016-03-31
NCT02380248	Clinical Evaluation of Systane® Gel Drops in Dry Eye Subjects	https://ClinicalTrials.gov/show/NCT02380248	Completed	Alcon Research	2016-06-01
NCT02369861	Study of ST266 Eye Drops in Treating Dry Eye	https://ClinicalTrials.gov/show/NCT02369861	Completed	Noveome Biotherapeutics, formerly Stemnion	2015-10-31
NCT02365519	LME636 in the Relief of Persistent Ocular Discomfort in Subjects With Severe Dry Eye Disease	https://ClinicalTrials.gov/show/NCT02365519	Completed	Alcon Research	2015-10-16
NCT02326090	Phase 2 Study With Cis-UCA Ophthalmic Solutions in Subjects With Dry Eye	https://ClinicalTrials.gov/show/NCT02326090	Completed	Herantis Pharma Plc.	2015-04-30
NCT02313454	Evaluation of the Safety and Effectiveness of the Oculeve Intranasal Lacrimal Neurostimulator in Patients With Dry Eye	https://ClinicalTrials.gov/show/NCT02313454	Completed	Allergan	2015-04-08
NCT02284516	A Study to Evaluate Efficacy and Safety of Lifitegrast in Subjects With Dry Eye (OPUS-3)	https://ClinicalTrials.gov/show/NCT02284516	Completed	Shire	2015-10-05
NCT02280473	A Safety and Efficacy Study of Refresh Optive® Gel Drops in Patients With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT02280473	Completed	Allergan	2015-03-16
NCT02260960	The Influence of PRN Dry Eye Omega-3 Nutritional Regimen on Tear Osmolarity In Cases Of Dry Eye Disease	https://ClinicalTrials.gov/show/NCT02260960	Completed	Physician Recommended Nutriceuticals	2015-03-31
NCT02254265	Phase 2/3 Dose-Ranging Study of the Safety and Efficacy of OTX-101 in the Treatment of Keratoconjunctivitis Sicca	https://ClinicalTrials.gov/show/NCT02254265	Completed	Sun Pharma Global FZE	2015-05-31
NCT02242032	Study of the Safety and Tolerability of P 321 Ophthalmic Solution in Subjects With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT02242032	Completed	Parion Sciences	2015-03-31
NCT02235259	Efficacy and Safety of XG-104 for the Treatment of Dry Eye	https://ClinicalTrials.gov/show/NCT02235259	Completed	Xigen SA	2015-02-28
NCT02229955	Study of Tisporin Eye Drops Group and Restasis Eye Drops Group After Treatment, Each Treatment Group Comparisons for Evaluation of Efficacy and Safety in Moderate to Severe Dry Eye Disease	https://ClinicalTrials.gov/show/NCT02229955	Completed	Hanlim Pharm. Co., Ltd.	2014-04-30
NCT02219204	Randomised Research Comparing Acupuncture, Herbal Treatment and Artificial Tear Eye Drops in Dry Eye	https://ClinicalTrials.gov/show/NCT02219204	Completed	Singapore National Eye Centre	2015-12-31
NCT02210793	Dry Eye Evaluation After Transepithelial PRK	https://ClinicalTrials.gov/show/NCT02210793	Completed	AL-Nour Eye Hospital	2013-03-31
NCT02205840	A Clinical Study Evaluating the Safety and Efficacy of SI-614 Ophthalmic Solution in Patients With Dry Eye.	https://ClinicalTrials.gov/show/NCT02205840	Completed	Seikagaku Corporation	2014-11-30
NCT02188160	Safety and Efficacy of KPI-121 in Subjects With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT02188160	Completed	Kala Pharmaceuticals, Inc.	2015-01-31
NCT02147509	Evaluation of Therapeutic Effect of Bandage Contact Lenses ( BCL) on Dry Eye Caused by Sjogren’s Syndrome	https://ClinicalTrials.gov/show/NCT02147509	Completed	Wenzhou Medical University	2014-04-30
NCT02139033	A Phase 4 Study Investigating the Efficacy of Retaineâ„¢ in Managing Signs and Symptoms Associated With Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT02139033	Completed	Ocusoft, Inc.	2014-05-31
NCT02128763	Dry Eye Assessment and Management Study	https://ClinicalTrials.gov/show/NCT02128763	Completed	University of Pennsylvania	2017-09-05
NCT02121847	Investigation of Maintaining Visual Performance Achieved With Cyclosporine Therapy	https://ClinicalTrials.gov/show/NCT02121847	Completed	Allergan	2014-09-23
NCT02121301	A Clinical Study to Assess the Safety and Efficacy of an Ophthalmic Solution (SkQ1) in the Treatment of Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT02121301	Completed	Mitotech, SA	2014-05-31
NCT02120079	The Utility of IVCM to Assess Cellular Response and Efficacy of Long-term Topical Steroid Treatment in Patients With DED	https://ClinicalTrials.gov/show/NCT02120079	Completed	Tufts Medical Center	2017-04-30
NCT02117687	A Safety and Efficacy Study of OPTIVE FUSION™ With VISMED® Multi for the Management of Dry Eye	https://ClinicalTrials.gov/show/NCT02117687	Completed	Allergan	2015-01-27
NCT02116244	Civamide Nasal Solution for the Treatment of Dry Eye	https://ClinicalTrials.gov/show/NCT02116244	Completed	Winston Laboratories	2015-09-30
NCT02102464	Treatment of Meibomian Gland Dysfunction and Dry Eye in Contact Lens Wearers	https://ClinicalTrials.gov/show/NCT02102464	Completed	TearScience, Inc.	2015-08-31
NCT02101281	Safety and Efficacy of rhNGF Eye Drops at Different Doses in Patients With Dry Eye	https://ClinicalTrials.gov/show/NCT02101281	Completed	Dompé Farmaceutici S.p.A	2015-01-31
NCT02100787	Changes in Tear Osmolarity Over Time With Sustained Use of TheraTears	https://ClinicalTrials.gov/show/NCT02100787	Completed	Jenkins Eye Care	2016-04-12
NCT02092207	Phase 2 Study to Evaluation the Safety and Efficacy of Orally Administered KL7016 in Patients With Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT02092207	Completed	Yungjin Pharm. Co., Ltd.	2014-06-30
NCT02078661	Safety and Efficacy of PG101 for Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT02078661	Completed	Rhodes Pharmaceuticals, L.P.	2014-01-31
NCT02066896	Laser Therapy to Treat the Dry Mouth of Sjogren’s Syndrome	https://ClinicalTrials.gov/show/NCT02066896	Completed	Federal University of São Paulo	2016-08-31
NCT01311609	A Multi-Site Post Marketing Surveillance Study for Systane in Indian Patients	https://ClinicalTrials.gov/show/NCT01311609	Completed	Alcon Research	2011-07-31
NCT01294956	A Clinical Evaluation of an Investigational Lubricant Eye Gel (FID 115958D)	https://ClinicalTrials.gov/show/NCT01294956	Completed	Alcon Research	2011-04-30
NCT01294384	Safety and Efficacy Study of New Eye Drop Formulations With Refresh Tears® in Patients With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT01294384	Completed	Allergan	2012-09-25
NCT01280110	The Effects of BAK on the Blood Aqueous Barrier of Pseudophakic Patients	https://ClinicalTrials.gov/show/NCT01280110	Completed	University of Campinas, Brazil	2011-12-31
NCT01278784	Local Tolerability of Chitosan-N-acetylcysteine Eye Drops in Healthy Young Volunteers	https://ClinicalTrials.gov/show/NCT01278784	Completed	Medical University of Vienna	2011-06-30
NCT01276223	Evaluation of Anti-Inflammatory Treatment in Dry Eye Patients	https://ClinicalTrials.gov/show/NCT01276223	Completed	Alcon Research	2012-01-31
NCT02023268	Efficacy and Safety of T2762 and Vismed® in Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT02023268	Completed	Laboratoires Thea	2014-12-31
NCT02051023	Efficacy and Safety of Fluorometholone (FML) in Dry Eye Disease (Keratoconjunctivitis Sicca)	https://ClinicalTrials.gov/show/NCT02051023	Completed	Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA	2014-12-31
NCT02028754	A Study of Sodium Carboxymethylcellulose for Post Cataract Surgery Dry Eye Symptoms	https://ClinicalTrials.gov/show/NCT02028754	Completed	Allergan	2013-05-31
NCT03785340	Study of Brimonidine Tartrate Nanoemulsion Eye Drop Solution in the Treatment of Dry Eye Disease (DED)	https://ClinicalTrials.gov/show/NCT03785340	Completed	Ocugen	2019-02-28
NCT02014922	A Study to Determine the Relief of Dry Eye Symptoms With the Use of TheraTears® Products (DUNLIN)	https://ClinicalTrials.gov/show/NCT02014922	Completed	University of Waterloo	2014-11-30
NCT02004067	Safety Study of the Use of Topical Cyclosporine in the Treatment of Dry Eye Disease	https://ClinicalTrials.gov/show/NCT02004067	Completed	Federal University of São Paulo	2016-08-31
NCT01998802	Phase 3 Study of EBI-005 in Dry Eye Disease	https://ClinicalTrials.gov/show/NCT01998802	Completed	Eleven Biotherapeutics	2015-03-31
NCT01991132	Validating the Diagnostic Accuracy of Mediview 2.0 Software as an Image Analysis Tool of Meibomian Glands	https://ClinicalTrials.gov/show/NCT01991132	Completed	Singapore National Eye Centre	2014-12-31
NCT01970917	Effect of Olixia Pure® Eye Drops on Tear Film Thickness in Healthy Subjects	https://ClinicalTrials.gov/show/NCT01970917	Completed	Medical University of Vienna	2013-11-30
NCT01967147	Clinical Outcomes Following Treatment With Systane® Balance in Dry Eye Subjects	https://ClinicalTrials.gov/show/NCT01967147	Completed	Alcon Research	2015-01-31
NCT01960010	A Safety and Efficacy Study of MIM-D3 Ophthalmic Solution for the Treatment of Dry Eye	https://ClinicalTrials.gov/show/NCT01960010	Completed	Mimetogen Pharmaceuticals USA, Inc.	2014-08-31
NCT01959854	Efficacy of Topical 0.2% Xanthan Gum in Patients With Dry Eye	https://ClinicalTrials.gov/show/NCT01959854	Completed	SIFI SpA	2014-10-31
NCT01933178	Reproducibility of Anterior Segment Optical Coherence Tomography (AS-OCT) for Imaging Conjunctivochalasis	https://ClinicalTrials.gov/show/NCT01933178	Completed	Singapore National Eye Centre	2014-02-28
NCT01918410	Effect of Contact Lens With Alginic Acid in Dry Eye Patients	https://ClinicalTrials.gov/show/NCT01918410	Completed	Singapore National Eye Centre	2014-12-31
NCT01900249	To Assess the Safety and Efficacy of R932348 Ophthalmic Solutions in Patients With Keratoconjunctivitis Sicca	https://ClinicalTrials.gov/show/NCT01900249	Completed	Rigel Pharmaceuticals	2014-07-31
NCT01890941	A Late Phase II Study of KCT-0809 in Patients With Dry Eye Syndromes	https://ClinicalTrials.gov/show/NCT01890941	Completed	Kissei Pharmaceutical Co., Ltd.	2014-03-31
NCT01880463	Dry Eye Disease in the Vitamin D and Omega-3 Trial (VITAL)	https://ClinicalTrials.gov/show/NCT01880463	Active, not recruiting	Brigham and Women’s Hospital	2020-12-31
NCT01864330	Influence of Lachrymal Substitutes on Tear Film Thickness in Patients With Moderate Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT01864330	Completed	Medical University of Vienna	2013-08-31
NCT01863368	Clinical Evaluation of Systane® ULTRA Compared to OPTIVE® in Ocular Surface Staining	https://ClinicalTrials.gov/show/NCT01863368	Completed	Alcon Research	2014-06-30
NCT01850979	Treatment of Dry Eye Using 0.03% Tacrolimus Eye Drops	https://ClinicalTrials.gov/show/NCT01850979	Completed	University of Sao Paulo General Hospital	2011-11-30
NCT01843894	A Phase 1/2, RU-101 Ophthalmic Solution in Patients With Severe Dry Eye	https://ClinicalTrials.gov/show/NCT01843894	Completed	R-Tech Ueno, Ltd.	2014-07-31
NCT01840787	A Pilot Study on the Use of a Sensory Panel to Assess Comfort Between Three Different Contact Lenses	https://ClinicalTrials.gov/show/NCT01840787	Completed	University of Waterloo	2014-01-31
NCT01833117	Efficacy and Safety Study of FID 119515A	https://ClinicalTrials.gov/show/NCT01833117	Completed	Alcon Research	2013-06-30
NCT01817582	Lotemax® Gel 0.5% and Restasis 0.05% in Participants With Mild or Moderate Keratoconjunctivitis Sicca (Dry Eye Disease)	https://ClinicalTrials.gov/show/NCT01817582	Completed	Bausch & Lomb Incorporated	2014-01-10
NCT01808560	Treatment of Meibomian Gland Dysfunction Prior to Cataract Surgery	https://ClinicalTrials.gov/show/NCT01808560	Completed	TearScience, Inc.	2015-01-31
NCT01804361	Efficacy and Safety Study of Haporine-S for Treatment of Moderate to Severe Dry Eye Syndromes	https://ClinicalTrials.gov/show/NCT01804361	Completed	DH Bio Co., Ltd.	2014-02-28
NCT01797822	Effects of Dry Eye Treatments on the Ocular Surface	https://ClinicalTrials.gov/show/NCT01797822	Completed	Baylor College of Medicine	2015-12-31
NCT01776658	Pilot Study to Evaluate SYL1001 Safety and Effect in Patients With Ocular Pain	https://ClinicalTrials.gov/show/NCT01776658	Completed	Sylentis, S.A.	2015-04-30
NCT01775540	Systane Ultra Versus Maxidex Versus Saline	https://ClinicalTrials.gov/show/NCT01775540	Completed	Icahn School of Medicine at Mount Sinai	2012-10-31
NCT01768312	Study of Cyclosporine Ophthalmic Soution Group and Cyclosporine Ophthalmic Suspension Group	https://ClinicalTrials.gov/show/NCT01768312	Completed	Hanlim Pharm. Co., Ltd.	2013-07-31
NCT01753752	Evaluation of the Corneal Residence Time of Chitosan-N-acetylcysteine Eye Drops in Patients With Dry Eye Syndrome After Single and Multiple Instillation	https://ClinicalTrials.gov/show/NCT01753752	Completed	Medical University of Vienna	2013-03-31
NCT01753687	Correlation of Different Signs for Assessment of Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT01753687	Completed	Medical University of Vienna	2013-07-31
NCT01748578	Phase 1 Study for Safety and Tolerability of EBI-005 Topically Administered to Eyes of Healthy Adult Subjects	https://ClinicalTrials.gov/show/NCT01748578	Completed	Eleven Biotherapeutics	2012-11-30
NCT01747616	Assessment of Safety and Tolerability of Chitosan-N-acetylcysteine Eye Drops in Subjects While Wearing Contact Lenses and Before Insertion of Contact Lenses	https://ClinicalTrials.gov/show/NCT01747616	Completed	Medical University of Vienna	2011-11-30
NCT01745887	A Multi-Center Study Subjects With Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT01745887	Completed	Eleven Biotherapeutics	2012-11-30
NCT01744457	Reproducibility of Tearfilm Osmolarity Measurements Using TearLab® in Patients With Dry Eye Syndrome and Healthy Subjects	https://ClinicalTrials.gov/show/NCT01744457	Completed	Medical University of Vienna	2012-02-29
NCT01743729	A Phase 3 Study to Evaluate the Efficacy of Lifitegrast in Subjects With Dry Eye	https://ClinicalTrials.gov/show/NCT01743729	Completed	Shire	2013-10-01
NCT01742884	Efficacy and Safety of a Treatment for Dry Eye Syndrome: Thealoz	https://ClinicalTrials.gov/show/NCT01742884	Completed	Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA	2014-06-30
NCT01733992	A Safety, Tolerability and Pharmacokinetics Study of R932348 Eye Drops in Patients With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT01733992	Completed	Rigel Pharmaceuticals	2013-02-28
NCT01733745	SYSTANE® Family - Meibomian Deficiency	https://ClinicalTrials.gov/show/NCT01733745	Completed	Alcon Research	2013-06-30
NCT01733732	SYSTANE® BALANCE Symptoms (OSDI) & Inflammatory Biomarkers	https://ClinicalTrials.gov/show/NCT01733732	Completed	Alcon Research	2013-10-31
NCT01692145	A Parallel Group Phase II Study of KCT-0809 in Patients With Dry Eye Syndromes	https://ClinicalTrials.gov/show/NCT01692145	Completed	Kissei Pharmaceutical Co., Ltd.	NA
NCT01688726	Evaluation of SYSTANE® BALANCE in Dry Eye Subjects With Lipid Deficiency	https://ClinicalTrials.gov/show/NCT01688726	Completed	Alcon Research	2013-11-30
NCT01684436	Safety and Efficacy of Punctal Plug Insertion in Patients With Dry Eye	https://ClinicalTrials.gov/show/NCT01684436	Completed	Allergan	2013-07-31
NCT01682460	Pilot Study on the Use of Artificial Tears to Treat Dry Eye in Glaucoma Patients	https://ClinicalTrials.gov/show/NCT01682460	Completed	University of Waterloo	2013-04-30
NCT01675570	A Study of RX-10045 in the Treatment of Dry Eye Disease	https://ClinicalTrials.gov/show/NCT01675570	Completed	C.T. Development America, Inc.	2012-11-30
NCT01670357	Phase II Study of DA-6034 Eye Drops in Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT01670357	Completed	Dong-A ST Co., Ltd.	2013-03-31
NCT01664949	A Study to Compare the Safety and Efficacy of A New Eye Drop Formulation With OPTIVEâ„¢ in Subjects With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT01664949	Completed	Allergan	2014-05-31
NCT01660256	Confirmatory Study of OPC-12759 Ophthalmic Solution	https://ClinicalTrials.gov/show/NCT01660256	Completed	Otsuka Pharmaceutical Co., Ltd.	2013-03-31
NCT01657253	Efficacy and Safety of PRO-148 Versus Systane®, in Patients With Mild to Moderate Dry Eye	https://ClinicalTrials.gov/show/NCT01657253	Completed	Laboratorios Sophia S.A de C.V.	2015-02-28
NCT01650584	Evaluation of Ocular Comfort With ISTA Tears vs Systane	https://ClinicalTrials.gov/show/NCT01650584	Completed	Bausch & Lomb Incorporated	2012-12-31
NCT01636206	Safety Study of Lifitegrast to Treat Dry Eye	https://ClinicalTrials.gov/show/NCT01636206	Completed	Shire	2014-03-03
NCT01632137	Efficacy and Safety of Rebamipide in Subjects With Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT01632137	Completed	Kubota Vision Inc.	2013-06-30
NCT01614600	Clinical Evaluation of a Daily Disposable Contact Lens in Symptomatic Weekly/Monthly Lens Wearers	https://ClinicalTrials.gov/show/NCT01614600	Completed	Alcon Research	2012-09-30
NCT01601028	Hydroxychloroquine Treatment of Dry Eyes in Patients With Primary Sjögren’s Syndrome	https://ClinicalTrials.gov/show/NCT01601028	Completed	Seoul National University Hospital	2013-08-31
NCT01579539	The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy	https://ClinicalTrials.gov/show/NCT01579539	Completed	Medical University of Vienna	2017-05-18
NCT01568593	Comparison of the Efficacy and Safety of T2750 and Vismed® in the Treatment of Moderate to Severe Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT01568593	Completed	Laboratoires Thea	2013-03-31
NCT01562795	Efficacy of Nonsteroidal Anti-inflammatory Drugs in Treatment of Moderate and Severe Dry Eye Disease	https://ClinicalTrials.gov/show/NCT01562795	Completed	Wenzhou Medical University	2012-06-30
NCT01558999	A Clinical Study Evaluating the Safety and Efficacy of SI-614 Ophthalmic Solution in Patients With Dry Eye	https://ClinicalTrials.gov/show/NCT01558999	Completed	Seikagaku Corporation	2012-07-31
NCT01543061	Efficacy Study of a New Eyedrop on Silicone Hydrogel Contact Lens Wearers With Dry Eye Complaints	https://ClinicalTrials.gov/show/NCT01543061	Completed	Optometric Technology Group Ltd	2012-09-30
NCT01541891	Efficacy and Safety of PRO-148 Ophthalmic Solution Versus SYSTANE® in the Treatment of Patients With Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT01541891	Completed	Laboratorios Sophia S.A de C.V.	2012-03-31
NCT01521507	Randomized Controlled Trial of Long-term Treatment Effectiveness for Meibomian Gland Dysfunction (MGD) and Dry Eye	https://ClinicalTrials.gov/show/NCT01521507	Completed	TearScience, Inc.	2013-11-30
NCT01483989	In Vivo Measurement of Corneal Epithelial Changes in Dry Eye Patients	https://ClinicalTrials.gov/show/NCT01483989	Completed	Alcon Research	2011-06-30
NCT01479790	Repeatability and Agreement of Anterior Segment Optical Coherence Tomography (AS-OCT) and Thermography	https://ClinicalTrials.gov/show/NCT01479790	Completed	Singapore National Eye Centre	2012-12-31
NCT01471093	Safety Study of OPC-12759 Ophthalmic Solution	https://ClinicalTrials.gov/show/NCT01471093	Completed	Otsuka Pharmaceutical Co., Ltd.	2011-12-31
NCT01468168	A Study Assessing the Safety and Efficacy of DE-101 Ophthalmic Suspension in Dry Eye Patients	https://ClinicalTrials.gov/show/NCT01468168	Completed	Santen Inc.	2012-11-30
NCT01459588	Safety, Efficacy, and Acceptability Study of an Eye Drop Formulation in Subjects With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT01459588	Completed	Allergan	2012-02-15
NCT01434277	Safety Evaluation of a New Preservative in a Lubricating Eye Drop	https://ClinicalTrials.gov/show/NCT01434277	Completed	Johnson & Johnson Consumer and Personal Products Worldwide	2011-04-30
NCT01427816	A Phase II Study of KCT-0809 in Patients With Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT01427816	Completed	Kissei Pharmaceutical Co., Ltd.	NA
NCT01421498	Safety and Efficacy Study of SAR 1118 to Treat Dry Eye Conducted in a Controlled Adverse Environment (CAE) (OPUS-1)	https://ClinicalTrials.gov/show/NCT01421498	Completed	Shire	2012-04-28
NCT01393132	Comparative Study of Thymosin Beta 4 Eye Drops vs. Vehicle in the Treatment of Severe Dry Eye	https://ClinicalTrials.gov/show/NCT01393132	Completed	Michigan Cornea Consultants, PC	2012-12-31
NCT01388426	Moisture Chamber Glasses for Dry Eye in Asian Population	https://ClinicalTrials.gov/show/NCT01388426	Completed	Singapore National Eye Centre	2012-08-31
NCT01387347	Safety and Efficacy of Thymosin Beta 4 Ophthalmic Solution in Patients With Dry Eye	https://ClinicalTrials.gov/show/NCT01387347	Completed	ReGenTree, LLC	2011-10-31
NCT01382225	Sodium Hyaluronate Ophthalmic Solution, 0.18% for Treatment of Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT01382225	Completed	Alcon Research	2012-05-31
NCT01375582	Objective Evaluation of Ocular Surface Lubricants in Two Environments	https://ClinicalTrials.gov/show/NCT01375582	Completed	University of Rochester	2012-06-30
NCT01363414	Sodium Hyaluronate and Wavefront Aberrations in Dry Eyes	https://ClinicalTrials.gov/show/NCT01363414	Completed	Ramathibodi Hospital	2010-06-30
NCT01339936	Evaluation of the Effect of Repeated Usage on the Tear Film Characteristics of an Investigational Eye Drop in Dry Eye Sufferers	https://ClinicalTrials.gov/show/NCT01339936	Completed	Optometric Technology Group Ltd	2011-08-31
NCT01319773	Study of Two Formulations of Cyclosporine Ophthalmic Emulsion in Healthy Volunteers and in Patients With Dry Eye	https://ClinicalTrials.gov/show/NCT01319773	Completed	Allergan	2011-01-31
NCT04425551	Effect of Micropulse Laser on Dry Eye Disease Due to Meibomian Gland Dysfunction	https://ClinicalTrials.gov/show/NCT04425551	Active, not recruiting	Naval Hospital, Athens	2020-09-30
NCT04384991	HU007 Eye Drops in Patients With Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT04384991	Completed	Huons Co., Ltd.	2019-12-05
NCT04362670	Study to Evaluate the Safety, Tolerability, and Efficacy of OTX-CSI in Subjects With Dry Eye Disease.	https://ClinicalTrials.gov/show/NCT04362670	Active, not recruiting	Ocular Therapeutix, Inc.	2020-11-30
NCT04343287	A Multi-Center, Randomized, Double Masked, Placebo Controlled Clinical Study to Assess the Safety and Efficacy of BRM421 for Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT04343287	Recruiting	BRIM Biotechnology Inc.	2020-04-30
NCT04342988	Effect of Cequa Treatment on Accuracy of Pre-operative Biometry & Higher Order Aberrations in Dry Eye Patients Undergoing Cataract Surgery	https://ClinicalTrials.gov/show/NCT04342988	Active, not recruiting	Research Insight LLC	2020-11-30
NCT04322656	Stability of Biometry in Meibomian Gland Dysfunction	https://ClinicalTrials.gov/show/NCT04322656	Recruiting	Vienna Institute for Research in Ocular Surgery	2021-03-31
NCT04320563	Rexon-Eye in Dry Eye	https://ClinicalTrials.gov/show/NCT04320563	Recruiting	Singapore National Eye Centre	2021-11-30
NCT04310969	Clinical Effect of MiboFlo in Dry Eye Patients	https://ClinicalTrials.gov/show/NCT04310969	Enrolling by invitation	Beijing Tongren Hospital	2020-05-30
NCT04280653	An Open-Label, Multi-Center, Clinical Study Evaluating the Effect of the NDE L68 StableFit® Punctal Plug on the Tear Lake	https://ClinicalTrials.gov/show/NCT04280653	Completed	Mati Therapeutics Inc.	2019-12-11
NCT04268069	Efficacy and Safety of PL9643 Ophthalmic Solution in Subjects With Dry Eye	https://ClinicalTrials.gov/show/NCT04268069	Recruiting	ORA, Inc.	2020-07-31
NCT04260893	Prospective Study To Assess The Safety And Effectiveness Of Tixel Treatment On Dry Eye Symptoms In Asian Patients	https://ClinicalTrials.gov/show/NCT04260893	Recruiting	Novoxel Ltd.	2021-04-30
NCT04237012	ACCURATE Study for Subjects With Dry Eyes	https://ClinicalTrials.gov/show/NCT04237012	Recruiting	The Eye Centers of Racine and Kenosha	2020-12-30
NCT04213248	Effect of UMSCs Derived Exosomes on Dry Eye in Patients With cGVHD	https://ClinicalTrials.gov/show/NCT04213248	Recruiting	Zhongshan Ophthalmic Center, Sun Yat-sen University	2020-05-31
NCT04201574	Phase 1/2a Safety and Efficacy of ALY688 Ophthalmic Solution in Subjects With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT04201574	Recruiting	Allysta Pharmaceutical	2020-08-31
NCT04184999	Effect of Intraoperative Dexamethasone on Post-op Dry Eye	https://ClinicalTrials.gov/show/NCT04184999	Active, not recruiting	SR Cornea Consultants	2019-12-31
NCT04181593	Phase 3 Study of the Safety and Efficacy of OmegaD Softgels in the Treatment of Dry Eye Disease	https://ClinicalTrials.gov/show/NCT04181593	Recruiting	OmegaD LLC	2020-07-31
NCT04165785	Efficiency and Changes of Cytokines Expression in Tear After Intense Pulsed Light Treating Dry Eye Disease	https://ClinicalTrials.gov/show/NCT04165785	Completed	First Affiliated Hospital of Harbin Medical University	2019-06-28
NCT04159935	Investigating iLux Efficacy in Contact Lens Wearers With Evaporative Dry Eye Disease	https://ClinicalTrials.gov/show/NCT04159935	Recruiting	University of Waterloo	2020-06-30
NCT04147650	Dose Ranging Study to Assess the Efficacy and Safety of Voclosporin Ophthalmic Solution in Subjects With Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT04147650	Recruiting	Aurinia Pharmaceuticals Inc.	2020-05-30
NCT04144413	3-year Study in Dry Eye Disease Patients With Severe Keratitis Receiving Ikervis® (1mg/mL Ciclosporin)	https://ClinicalTrials.gov/show/NCT04144413	Recruiting	Santen SAS	2023-05-31
NCT04143841	Viveye Ocular Magnetic Neurostimulation System (OMNS) for the Management of Severe Dry Eye Disease	https://ClinicalTrials.gov/show/NCT04143841	Recruiting	Epitech Mag Ltd.	2020-10-31
NCT04139122	Safety, PK and Efficacy Study of SJP-0132 in Subjects With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT04139122	Completed	Senju Pharmaceutical Co., Ltd.	2020-03-03
NCT04120584	Clinical Evaluation of Safety and Efficacy of Radio Frequency (Forma Eye) Treatment for Dry Eye Disease Due to Meibomian Gland Dysfunction	https://ClinicalTrials.gov/show/NCT04120584	Recruiting	InMode MD Ltd.	2020-10-31
NCT04115800	Liposomal Sirolimus in Dry Eye Disease	https://ClinicalTrials.gov/show/NCT04115800	Recruiting	Instituto de Oftalmología Fundación Conde de Valenciana	2020-05-01
NCT04105842	Refitting Daily Disposable Contact Lens Wearers With Dry Eye Disease With A Different Daily Disposable Lens Type	https://ClinicalTrials.gov/show/NCT04105842	Recruiting	University of Waterloo	2020-02-28
NCT04100031	Efficacy of an Ocular Bandage Contact Lens for the Treatment of Dry Eye After Cataract Surgery	https://ClinicalTrials.gov/show/NCT04100031	Recruiting	Second Affiliated Hospital, School of Medicine, Zhejiang University	2020-06-06
NCT04096898	Senofilcon A Lenses in Moderate to Severe Dry Eye Disease	https://ClinicalTrials.gov/show/NCT04096898	Recruiting	University of Illinois at Chicago	2020-12-31
NCT04092907	A Study Evaluating the Efficacy and Safety on Moderate to Severe Dry Eye	https://ClinicalTrials.gov/show/NCT04092907	Completed	Harbour BioMed (Guangzhou) Co. Ltd.	2019-07-03
NCT04091581	Comparison of Tear Evaporation Rate With Systane Complete in Dry Eye and Non-Dry Eye	https://ClinicalTrials.gov/show/NCT04091581	Completed	University of Waterloo	2020-02-06
NCT04084483	A Study Assessing the Safety, Efficacy, and Optimum Dosage of K-161 in Subjects With Moderate to Severe Dry Eye Disease	https://ClinicalTrials.gov/show/NCT04084483	Completed	Kowa Research Institute, Inc.	2020-01-03
NCT04081610	Clinical Trial to Evaluate the Safety and Tolerability of Lagricel® Ofteno Multi-dose Ophthalmic Solution	https://ClinicalTrials.gov/show/NCT04081610	Recruiting	Laboratorios Sophia S.A de C.V.	2019-12-20
NCT04063735	Alleviating Effects Against Dry Eye by Oral Intake of Cordyceps Cicadae Mycelia	https://ClinicalTrials.gov/show/NCT04063735	Completed	Chung Shan Medical University	2017-02-07
NCT04063644	Quality of Life and Visual Acuity of Visglyc Eye Drops on Dry Eye Patients	https://ClinicalTrials.gov/show/NCT04063644	Recruiting	OPKO Health, Inc.	2020-05-31
NCT04036292	Clinical Trial to Evaluate the Efficacy of OC-01 (Varenicline) Nasal Spray on Signs and Symptoms of Dry Eye Disease (The ONSET-2 Study)	https://ClinicalTrials.gov/show/NCT04036292	Active, not recruiting	Oyster Point Pharma, Inc.	2020-05-08
NCT04022382	A Study to Evaluate the Safety and Effectiveness Assessments of Restylane-Defyne for Punctual Occlusion	https://ClinicalTrials.gov/show/NCT04022382	Completed	The Eye Care Institute	2019-08-26
NCT04015219	Management of Signs and Symptoms Associated With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT04015219	Recruiting	Tissue Tech Inc.	2020-07-01
NCT03992482	IVIG-eye Drops Treatment for Dry Eye Disease	https://ClinicalTrials.gov/show/NCT03992482	Completed	University of Illinois at Chicago	2019-08-02
NCT03992287	Efficacy and Safety of Hydrolysed Red Ginseng Extract on Dry Eye	https://ClinicalTrials.gov/show/NCT03992287	Recruiting	Chonbuk National University Hospital	2020-03-30
NCT03982368	A Study to Evaluate Safety and Efficacy of rhNGF Eye Solution vs Vehicle in Patients With Moderate to Severe Dry Eye	https://ClinicalTrials.gov/show/NCT03982368	Recruiting	Dompé Farmaceutici S.p.A	2020-03-31
NCT03968731	Meibomian Gland Dysfunction Management With ZEST Protocol	https://ClinicalTrials.gov/show/NCT03968731	Recruiting	University of the Incarnate Word	2020-03-31
NCT03956225	Comparison Between iLux and LipiFlow in the Treatment of Meibomian Gland Dysfunction (MGD): A 12-month, Multicenter Study	https://ClinicalTrials.gov/show/NCT03956225	Active, not recruiting	Alcon Research	2020-10-31
NCT03925727	Tavilermide Ophthalmic Solution for the Treatment of Dry Eye	https://ClinicalTrials.gov/show/NCT03925727	Recruiting	Mimetogen Pharmaceuticals USA, Inc.	2020-02-29
NCT03923244	Dry Eye Syndrome Description During Cataract Surgery, With Multimodal Analysis of the Ocular Surface	https://ClinicalTrials.gov/show/NCT03923244	Completed	University Hospital, Clermont-Ferrand	2020-03-06
NCT03916042	A Multi-Center, Randomized, Double-Masked, Parallel-Group, Vehicle-Controlled, Clinical Trial of Reproxalap to Assess the Safety and Efficacy in Subjects With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT03916042	Active, not recruiting	Aldeyra Therapeutics, Inc.	2020-04-30
NCT03907865	Clinical Efficacy of Topical Hydrocortisone 0.335% (Softacort®) in Patients With Chronic Dry Eye Disease and Associated Ocular Surface Inflammation	https://ClinicalTrials.gov/show/NCT03907865	Completed	Medical University of Vienna	2018-11-28
NCT03889886	Study to Evaluate the Safety and Efficacy of SDP-4 in Subjects With Dry Eye Disease (DED)	https://ClinicalTrials.gov/show/NCT03889886	Active, not recruiting	Silk Technologies, Ltd.	2020-01-31
NCT03879863	The RENEW Trial: A Multi-Center, Randomized, Double-Masked, Parallel-Group, Vehicle-Controlled, Adaptive Phase 3 Clinical Trial to Assess the Safety and Efficacy of Subjects With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT03879863	Active, not recruiting	Aldeyra Therapeutics, Inc.	2021-04-30
NCT03874429	Efficacy of T2259 in DED	https://ClinicalTrials.gov/show/NCT03874429	Recruiting	Laboratoires Thea	2020-03-01
NCT03873246	Clinical Trial to Evaluate the Chronic Efficacy of OC-01 Nasal Spray on Signs of Dry Eye Disease (The MYSTIC Study)	https://ClinicalTrials.gov/show/NCT03873246	Completed	Oyster Point Pharma, Inc.	2020-01-07
NCT03865888	Comparing Effect of Topical Tacrolimus 0.03% Versus Cyclosporine 0.05% in Dry Eyes of Secondary Sjogren Syndrome	https://ClinicalTrials.gov/show/NCT03865888	Completed	Cairo University	2019-02-01
NCT03857919	TearCare System to Treat Dry Eye Disease	https://ClinicalTrials.gov/show/NCT03857919	Recruiting	Sight Sciences, Inc.	2019-10-31
NCT03848221	Direct Application of Systane Complete to Contact Lenses	https://ClinicalTrials.gov/show/NCT03848221	Completed	University of Alabama at Birmingham	2019-10-20
NCT03846453	A Study to Assess Efficacy and Safety of HL036 in Subjects With Dry Eyes	https://ClinicalTrials.gov/show/NCT03846453	Recruiting	HanAll BioPharma Co., Ltd.	2019-11-30
NCT03833882	Evaluation of MAF-1217 in Patients With DED	https://ClinicalTrials.gov/show/NCT03833882	Completed	VISUfarma SpA	2019-06-19
NCT03833388	Study of TOP1630 for Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT03833388	Completed	Topivert Pharma Ltd	2019-05-14
NCT03830359	T2769 in Dry Eye Disease	https://ClinicalTrials.gov/show/NCT03830359	Completed	Laboratoires Thea	2019-02-18
NCT03827564	Goblet Cell Degranulation Produced by Intranasal Tear Neurostimulator (ITN) in Dry Eye Disease	https://ClinicalTrials.gov/show/NCT03827564	Recruiting	Allergan	2020-06-30
NCT03804502	Pilot Study of TearCare System - Long-Term Extension	https://ClinicalTrials.gov/show/NCT03804502	Active, not recruiting	Sight Sciences, Inc.	2019-07-31
NCT03803748	A Non-inferiority Study of Eyestil® Plus Multidose Versus Vismed Multi®	https://ClinicalTrials.gov/show/NCT03803748	Recruiting	SIFI SpA	2020-06-30
NCT03803722	To Demonstrate the Non-inferiority of Eyestil Protection® Compared to Vismed® in Terms of Clinical Performance	https://ClinicalTrials.gov/show/NCT03803722	Recruiting	SIFI SpA	2020-06-30
NCT03764735	Study of SkQ1 as Treatment for Dry-eye Syndrome	https://ClinicalTrials.gov/show/NCT03764735	Completed	Mitotech, SA	2019-02-09
NCT03747614	Ocular Micro-vascular Research Base on Functional Slip Lamp Biomicroscopy	https://ClinicalTrials.gov/show/NCT03747614	Recruiting	Zhongshan Ophthalmic Center, Sun Yat-sen University	2020-06-30
NCT03723811	Clinical Study to Investigate the Efficacy and Safety of SJP002 Ophthalmic Solution in Patients With Dry Eye Syndrome.	https://ClinicalTrials.gov/show/NCT03723811	Active, not recruiting	Samjin Pharmaceutical Co., Ltd.	2018-06-25
NCT03723798	Clinical Study to Investigate the Efficacy and Safety of Orally Administered SA001 in Patients With Dry Eye Syndrome.	https://ClinicalTrials.gov/show/NCT03723798	Active, not recruiting	Samjin Pharmaceutical Co., Ltd.	2018-10-08
NCT03719885	TrueTear in Sjogren’s Disease Patients	https://ClinicalTrials.gov/show/NCT03719885	Recruiting	University of Pennsylvania	2019-07-25
NCT03709641	A Study to Evaluate the Safety and Effectiveness of Restylane-Defyne for Punctual Occlusion	https://ClinicalTrials.gov/show/NCT03709641	Completed	The Eye Care Institute	2018-11-28
NCT03706443	Tear Lipid Layer Thickness Changes With Use of Emollient and Non-Emollient Eye Drops	https://ClinicalTrials.gov/show/NCT03706443	Completed	Ohio State University	2019-02-28
NCT03697876	Safety and Tolerability of the Ophthalmic Gel PRO-165 Versus Artelac® Nightime Gel	https://ClinicalTrials.gov/show/NCT03697876	Active, not recruiting	Laboratorios Sophia S.A de C.V.	2019-08-31
NCT03693183	Efficacy Study of Ketorolac and HPMC to Treat Dry Eye	https://ClinicalTrials.gov/show/NCT03693183	Completed	ORA, Inc.	2009-06-15
NCT03691636	Eyelash Prostheses Compared to 5.0% Lifitegrast BID for Dry Eye Disease.	https://ClinicalTrials.gov/show/NCT03691636	Recruiting	D.E.L., LLC	2019-04-02
NCT03688802	Clinical Trial to Evaluate the Efficacy of OC-01 Nasal Spray on Goblet Cell and Meibomian Gland Stimulation (The IMPERIAL Study)	https://ClinicalTrials.gov/show/NCT03688802	Completed	Oyster Point Pharma, Inc.	2019-09-30
NCT03682809	Evaluation of Systane Complete for the Treatment of Contact Lens Discomfort	https://ClinicalTrials.gov/show/NCT03682809	Completed	University of Alabama at Birmingham	2019-03-23
NCT03666884	The Comparison of 50% AS Versus PFAT+ 0.05 % COE in Severe Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT03666884	Completed	Usak State Hospital	2016-03-15
NCT03660475	Effect of Topical Naltrexone Ophthalmic Solution on the Signs and Symptoms of Dry Eye in Diabetic Subjects	https://ClinicalTrials.gov/show/NCT03660475	Completed	Total Eye Care, PA	2018-11-01
NCT03658811	Intense Pulse Light Treatment With Meibomian Gland Expression of the Upper Eyelids in Dry Eye Disease	https://ClinicalTrials.gov/show/NCT03658811	Completed	Toyos Clinic	2018-10-30
NCT03652051	A Multicenter Study Evaluating AZR-MD-001 in Patients With Meibomian Gland Dysfunction and Evaporative Dry Eye Disease (DED)	https://ClinicalTrials.gov/show/NCT03652051	Recruiting	Azura Ophthalmics	2020-12-31
NCT03640351	Clinical Effects of Diquas-S for Patients With Dry Eye After Cataract Surgery	https://ClinicalTrials.gov/show/NCT03640351	Recruiting	Yonsei University	2019-08-14
NCT03636061	Clinical Trial to Evaluate the Efficacy of OC-01 Nasal Spray on Signs and Symptoms of Dry Eye Disease (The ONSET-1 Study)	https://ClinicalTrials.gov/show/NCT03636061	Completed	Oyster Point Pharma, Inc.	2018-09-26
NCT03633461	Clinical Trial to Evaluate the Efficacy of OC-02 Nasal Spray on Signs and Symptoms of Dry Eye Disease (The RAINIER Study)	https://ClinicalTrials.gov/show/NCT03633461	Completed	Oyster Point Pharma, Inc.	2018-09-20
NCT03622619	The Effect of Manuka Eye Drops on Tear Film Properties	https://ClinicalTrials.gov/show/NCT03622619	Completed	The University of New South Wales	2018-10-30
NCT03617315	Crosslinked Hyaluronic Acid With Liposomes and Crocin in Dry Eye	https://ClinicalTrials.gov/show/NCT03617315	Completed	University of Seville	2018-02-01
NCT03616899	Safety and Efficacy of KPI-121 in Subjects With DED	https://ClinicalTrials.gov/show/NCT03616899	Completed	Kala Pharmaceuticals, Inc.	2020-02-05
NCT03608761	Comparison Between Rebamipide 2% Versus Autologous Serum	https://ClinicalTrials.gov/show/NCT03608761	Completed	Hospital Nacional Profesor Alejandro Posadas	2017-10-09
NCT03598699	A Study to Evaluate the Safety, Tolerability, Systemic Pharmacokinetics, and Pharmacodynamics of AXR-159 Ophthalmic Solution in Patients With Dry Eye Disease (DED)	https://ClinicalTrials.gov/show/NCT03598699	Active, not recruiting	AxeroVision, Inc.	2019-03-31
NCT03597139	Ocular Tolerability of Voclosporin Ophthalmic Solution Versus Restasis® in Subjects With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT03597139	Completed	Aurinia Pharmaceuticals Inc.	2018-11-09
NCT03588624	Study of the TearCare System in Dry Eye Disease	https://ClinicalTrials.gov/show/NCT03588624	Recruiting	Sight Sciences, Inc.	2018-09-30
NCT03569202	Piiloset Trehalose Emulsion Eye Drop Study in Moderate or Severe Dry Eye	https://ClinicalTrials.gov/show/NCT03569202	Completed	Kuopio University Hospital	2018-11-08
NCT03539159	Assessment of the Mu-Drop System for Serum Eye Drops	https://ClinicalTrials.gov/show/NCT03539159	Recruiting	Sanquin Research & Blood Bank Divisions	2019-12-01
NCT03527212	A Study to Assess the Safety and Effectiveness of SJP-0035 for the Treatment of Patients With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT03527212	Completed	Senju Pharmaceutical Co., Ltd.	2019-03-15
NCT03524157	Safety and Tolerability of PRO-087 Versus Xyel Ofteno® and Systane Ultra®, on the Ocular Surface of Healthy Subjects	https://ClinicalTrials.gov/show/NCT03524157	Completed	Laboratorios Sophia S.A de C.V.	2018-02-12
NCT03520348	Safety and Tolerability of the Ophthalmic Gel PRO-167 Versus Corneregel® on Healthy Subjects.	https://ClinicalTrials.gov/show/NCT03520348	Completed	Laboratorios Sophia S.A de C.V.	2018-05-22
NCT03519815	Clinical Study to Evaluate the Efficacy of Ectoin® Containing Eye Spray for Treatment of Dry Eye Disease	https://ClinicalTrials.gov/show/NCT03519815	Completed	University of Applied Sciences and Arts Northwestern Switzerland	2018-10-30
NCT03518398	Effectiveness and Safety of Intense Pulsed Light in Patients With Meibomian Gland Dysfunction	https://ClinicalTrials.gov/show/NCT03518398	Completed	Chulalongkorn University	2019-04-02
NCT03492541	Study of Efficacy and Tolerability of SYSTANE Complete in Patients With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT03492541	Completed	Alcon Research	2019-04-30
NCT03467490	Self-care Management Program for Dry Eye Disease Patients Using the heiQ	https://ClinicalTrials.gov/show/NCT03467490	Active, not recruiting	Lawson Health Research Institute	2019-01-19
NCT03452397	Clinical Trial to Evaluate the Efficacy of OC-02 Nasal Spray on Signs and Symptoms of Dry Eye Disease (The PEARL Study)	https://ClinicalTrials.gov/show/NCT03452397	Completed	Oyster Point Pharma, Inc.	2018-05-16
NCT03436576	Efficacy of Two Concentrations of Autologous Serum for the Treatment of Severe Dry Eye	https://ClinicalTrials.gov/show/NCT03436576	Enrolling by invitation	Pontificia Universidad Catolica de Chile	2018-10-19
NCT03418727	Dry Eye Disease Study With Brimonidine	https://ClinicalTrials.gov/show/NCT03418727	Completed	Ocugen	2018-03-29
NCT03417505	Tangible Hydra-PEG: A Promising Solution for Scleral Lens Wearers With Dry Eye	https://ClinicalTrials.gov/show/NCT03417505	Completed	Tangible Science	2019-01-04
NCT03414645	Topical Fibrinogen-Depleted Human Platelet Lysate in Patients With Dry Eye Secondary to Graft vs. Host Disease	https://ClinicalTrials.gov/show/NCT03414645	Recruiting	Cambium Medical Technologies LLC	2019-09-30
NCT01268735	The Effect of Ocular Lubricant Eyedrops on Lid Parallel Conjunctival Folds and Other Signs and Symptoms of Dry Eye	https://ClinicalTrials.gov/show/NCT01268735	Completed	University of Zagreb	2009-09-30
NCT01257607	Safety and Efficacy Study of MIM-D3 Ophthalmic Solution for the Treatment of Dry Eye	https://ClinicalTrials.gov/show/NCT01257607	Completed	Mimetogen Pharmaceuticals USA, Inc.	2011-05-31
NCT01252121	Residence Time Evaluation of Systane Ultra Lubricant Eye Drops vs. Hialid and Saline	https://ClinicalTrials.gov/show/NCT01252121	Completed	Alcon Research	2011-06-30
NCT01250171	The Effects of a Single Intravenous Administration of Secukinumab (AIN457) or Canakinumab (ACZ885) in Dry Eye Patients	https://ClinicalTrials.gov/show/NCT01250171	Completed	Novartis	2011-09-30
NCT01240382	Phase III Confirmatory Study of DE-089 Ophthalmic Solution in Patients With Dry Eye	https://ClinicalTrials.gov/show/NCT01240382	Completed	Santen Pharmaceutical Co., Ltd.	2008-02-29
NCT01239069	Safety and Efficacy Study of DE-110 Ophthalmic Suspension for the Treatment of Dry Eye Disease	https://ClinicalTrials.gov/show/NCT01239069	Completed	Santen Inc.	2011-10-31
NCT01235234	Trial of CF101 to Treat Patients With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT01235234	Completed	Can-Fite BioPharma	2013-11-30
NCT01223040	An Open-Label, Single-Center Study Evaluating the Effect of Systane Balance on Video Ocular Protection Index (OPI) and Blink Patterns in Patients Diagnosed With Dry Eye	https://ClinicalTrials.gov/show/NCT01223040	Completed	Alcon Research	2010-09-30
NCT01212471	A Dose Ranging Study to Evaluate Safety and Efficacy of Bromfenac Ophthalmic Solution in Dry Eye Disease	https://ClinicalTrials.gov/show/NCT01212471	Completed	Bausch & Lomb Incorporated	2011-08-31
NCT01211951	A Study of KCT-0809 in Patients With Dry Eye Syndromes	https://ClinicalTrials.gov/show/NCT01211951	Completed	Kissei Pharmaceutical Co., Ltd.	NA
NCT01203540	Evaluation of the Effect and Tolerance of Preservative Free NAAGA on the Inflammatory Component and Symptoms of Dry Eye Syndrome in Allergic Conjunctivitis Patients	https://ClinicalTrials.gov/show/NCT01203540	Completed	Laboratoires Thea	NA
NCT01202747	Evaluation of Screening Methods for Treatment of Meibomian Gland Dysfunction	https://ClinicalTrials.gov/show/NCT01202747	Completed	TearScience, Inc.	2011-01-31
NCT01198782	Evaluating Safety and Efficacy of FID 112903 Post Discontinuation of Long-term Use of RESTASIS® (Cyclosporine Ophthalmic Emulsion) 0.05%	https://ClinicalTrials.gov/show/NCT01198782	Completed	Alcon Research	2011-05-31
NCT01189032	Late Phase II Confirmatory Study of DE-089 Ophthalmic Solution in Patients With Dry Eye	https://ClinicalTrials.gov/show/NCT01189032	Completed	Santen Pharmaceutical Co., Ltd.	2006-07-31
NCT01178242	Salivary Gland Transplantation in the Treatment of Dry Eye in Patients With Stevens-Johnson Syndrome.	https://ClinicalTrials.gov/show/NCT01178242	Completed	Federal University of São Paulo	2010-04-30
NCT01165164	An Evaluation of the Nighttime Retention of Effect of an Investigational Lubricant Eye Drop (FID 115958D)	https://ClinicalTrials.gov/show/NCT01165164	Completed	Alcon Research	2010-07-31
NCT01163643	Study to Assess the Safety and Efficacy of BOL-303242-X Ophthalmic Suspension in Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT01163643	Completed	Bausch & Lomb Incorporated	2011-06-30
NCT01162954	Phase I Study to Evaluate the Tolerability of Eye Drop DA-6034 in Healthy Volunteers	https://ClinicalTrials.gov/show/NCT01162954	Completed	Dong-A ST Co., Ltd.	2009-03-31
NCT01160133	To Evaluate the Physical Effects of Systane(R) Lubricant Eye Drops Compared to Refresh Tears(R) Lubricant Eye Drops	https://ClinicalTrials.gov/show/NCT01160133	Completed	Alcon Research	2011-06-30
NCT01139372	An Evaluation of the Daytime Use of an Investigational Lubricant Eye Drop	https://ClinicalTrials.gov/show/NCT01139372	Completed	Alcon Research	2010-06-30
NCT01135511	A Phase II, Dose Ranging Study Of CP-690,550 Eye Drops In Patients With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT01135511	Completed	Pfizer	2011-04-30
NCT01129856	Safety and Efficacy Study of EGP-437 (Dexamethasone Phosphate Formulated for Ocular Iontophoresis) to Treat Dry Eye	https://ClinicalTrials.gov/show/NCT01129856	Completed	Eyegate Pharmaceuticals, Inc.	2011-01-31
NCT01128049	Non-invasive Tear Film Dynamic Measurements in Normal, MGD and ADDE Subjects After Saline Instillation	https://ClinicalTrials.gov/show/NCT01128049	Completed	University of Rochester	2011-12-31
NCT01118754	Study Assessing Safety and Efficacy of DE-101 Ophthalmic Suspension in Dry Eye Patients	https://ClinicalTrials.gov/show/NCT01118754	Completed	Santen Inc.	2010-12-31
NCT01107964	Oral Omega-3 Fatty Acids in the Treatment of Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT01107964	Completed	Milton S. Hershey Medical Center	2014-08-31
NCT01105910	Efficacy of Systane Ultra in Post Menopausal Women With Dry Eye	https://ClinicalTrials.gov/show/NCT01105910	Completed	Alcon Research	2010-12-31
NCT01105624	A Four Week Study of Azithromycin Ophthalmic Solution, 1% Versus Rewetting Drops in Subjects With History and Current Complaint of Contact Lens-Related Dry Eye (CLDE)	https://ClinicalTrials.gov/show/NCT01105624	Completed	Merck Sharp & Dohme Corp.	2010-11-30
NCT01105221	Acupuncture for Dry Eye	https://ClinicalTrials.gov/show/NCT01105221	Completed	Korea Institute of Oriental Medicine	2010-11-30
NCT01102257	Dry Eye Assessment and Management: Feasibility Study	https://ClinicalTrials.gov/show/NCT01102257	Completed	Asbell, Penny, M.D.	2010-07-31
NCT01101984	Study of DE-089 Ophthalmic Solution in Patients With Dry Eye	https://ClinicalTrials.gov/show/NCT01101984	Completed	Santen Pharmaceutical Co., Ltd.	NA
NCT01086774	Efficacy of Systane Balance to Stabilize the Tear Film in Dry Eye Subjects	https://ClinicalTrials.gov/show/NCT01086774	Completed	Alcon Research	2010-11-30
NCT01077011	Acute Comfort and Blur Profile of a Lubricant Eye Drop Versus a Marketed Lubricant Eye Gel	https://ClinicalTrials.gov/show/NCT01077011	Completed	Alcon Research	2010-01-31
NCT01076998	Acute Comfort and Blur Profile of a Lubricant Eye Drop Versus a Marketed Eye Ointment	https://ClinicalTrials.gov/show/NCT01076998	Completed	Alcon Research	2010-01-31
NCT01061268	A Clinical Evaluation Pilot Study of the Efficacy of Blink® Tears Lubricant Eye Drops for the Relief of Dry Eye Symptoms Following Implantation of Tecnis® Multifocal Introcular Lens	https://ClinicalTrials.gov/show/NCT01061268	Completed	Innovative Medical	2012-02-29
NCT01057147	Safety and Efficacy Study of Rebamipide 2% Ophthalmic Suspension in Subjects With Dry Eye - Effects on Central Cornea	https://ClinicalTrials.gov/show/NCT01057147	Completed	Kubota Vision Inc.	2011-01-31
NCT01051804	Evaluation of the Repeated Usage of Systane Ultra Eyedrop	https://ClinicalTrials.gov/show/NCT01051804	Completed	Alcon Research	2010-07-31
NCT01027013	Safety and Efficacy Study of Rebamipide 2% Ophthalmic Suspension in Patients With Dry Eye	https://ClinicalTrials.gov/show/NCT01027013	Completed	Kubota Vision Inc.	2010-10-31
NCT01015209	Safety and Tolerability of Chitosan-N-acetylcysteine Eye Drops in Healthy Young Volunteers	https://ClinicalTrials.gov/show/NCT01015209	Completed	Medical University of Vienna	2010-10-31
NCT01014078	A Four Week Study of Azithromycin Ophthalmic Solution, 1% Versus Placebo in Subjects With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT01014078	Completed	Merck Sharp & Dohme Corp.	2010-03-31
NCT01013077	The Effect of a New Emulsion in Dry Eye Patients on Tear Layer Aberrometry, Contrast Sensitivity, and Reading Ability	https://ClinicalTrials.gov/show/NCT01013077	Completed	Southern California College of Optometry	2011-03-31
NCT01010282	Safety and Efficacy of Two Artificial Tears in Dry Eye Subjects	https://ClinicalTrials.gov/show/NCT01010282	Completed	Allergan	2010-04-30
NCT00995189	Clinical Evaluation of the Causes of Contact Lens Related Dry Eye	https://ClinicalTrials.gov/show/NCT00995189	Completed	Alcon Research	2010-04-30
NCT00987727	Safety and Efficacy of Carboxymethylcellulose for Ocular Surface Integrity in Symptomatic Dry Eye	https://ClinicalTrials.gov/show/NCT00987727	Completed	Allergan	2010-07-31
NCT00983203	Acute Comfort and Haze Profile of FID 114657	https://ClinicalTrials.gov/show/NCT00983203	Completed	Alcon Research	2009-08-31
NCT00969280	Acupuncture for Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT00969280	Completed	Korea Institute of Oriental Medicine	2009-12-31
NCT00946777	Barrier Function Measurement in Dry Eye Patients After Using Systane Ultra for 30 Days	https://ClinicalTrials.gov/show/NCT00946777	Completed	Alcon Research	2009-09-30
NCT00938951	Evaluate the Ability of Systane Ultra to Improve Subjective Symptoms of Ocular Irritation Post 60 Min. Athletic Performance.	https://ClinicalTrials.gov/show/NCT00938951	Completed	Alcon Research	2009-07-31
NCT00938704	Study to Compare the Efficacy and Safety of Two Non-Preserved Artificial Tears for the Treatment of Dry Eye Signs and Symptoms	https://ClinicalTrials.gov/show/NCT00938704	Completed	Allergan	2009-06-30
NCT00932477	Safety and Tolerability of Artificial Tears in Dry Eye Subjects	https://ClinicalTrials.gov/show/NCT00932477	Completed	Allergan	2009-09-30
NCT00926185	A Study Evaluating the Efficacy of SAR 1118 (0.1%, 1.0%, 5.0%) Ophthalmic Solution in Subjects With Dry Eye Conducted in a Controlled Adverse Environment (CAE)	https://ClinicalTrials.gov/show/NCT00926185	Completed	Shire	2010-02-28
NCT00909324	Efficacy, Tolerability, and Comfort of 0.3% Hypromellose Eyedrops in Patients Undergoing LASIK Surgery	https://ClinicalTrials.gov/show/NCT00909324	Completed	Novartis	2010-01-31
NCT00893139	A Study of AL-38583 Ophthalmic Solution 0.05%, 0.010% Versus AL-38583 Vehicle for Dry Eye	https://ClinicalTrials.gov/show/NCT00893139	Completed	Alcon Research	2010-01-31
NCT00885079	Confirmatory Study of OPC-12759 Ophthalmic Suspension	https://ClinicalTrials.gov/show/NCT00885079	Completed	Otsuka Pharmaceutical Co., Ltd.	2010-03-31
NCT00883649	Efficacy and Safety Study of Nutritional Supplements for Treatments of Dry Eye	https://ClinicalTrials.gov/show/NCT00883649	Completed	Virginia Eye Consultants	2011-12-31
NCT00851734	A Dose-Escalation Study to Assess the Safety and Tolerability of LX214 Ophthalmic Solution in Healthy Volunteers, Followed by an Open-Label Evaluation of LX214 in Patients With Keratoconjunctivitis Sicca (KCS)	https://ClinicalTrials.gov/show/NCT00851734	Completed	Lux Biosciences, Inc.	2009-03-31
NCT00840268	A Study of Hydroxypropyl Guar Galactomannan 0.25% (HPGG) Versus Vehicle in Dry Eye Patients	https://ClinicalTrials.gov/show/NCT00840268	Completed	Alcon Research	2009-07-31
NCT04206020	Vehicle-Controlled Study of SkQ1 as Treatment for Dry-eye Syndrome	https://ClinicalTrials.gov/show/NCT04206020	Recruiting	Mitotech, SA	2020-09-15
NCT04172961	Clinical Efficacy of Two Topical Dry Eye Drops for Central Corneal Stain Clearing Over 90 Days	https://ClinicalTrials.gov/show/NCT04172961	Recruiting	Toyos Clinic	2020-05-01
NCT04093037	Analysis of the Diagnostic Performance of LacryDiag, a New Analyzer of the Ocular Surface in the Dry Eye	https://ClinicalTrials.gov/show/NCT04093037	Recruiting	Centre Hospitalier Universitaire de Saint Etienne	2021-07-31
NCT03878628	Treatment With Allogeneic Adipose-derived Mesenchymal Stem Cells in Patients With Aqueous Deficient Dry Eye Disease	https://ClinicalTrials.gov/show/NCT03878628	Recruiting	Rigshospitalet, Denmark	2020-04-30
NCT03461575	Efficacy and Safety of HU007 Eye Drops in Patients With Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT03461575	Completed	Huons Co., Ltd.	2018-07-12
NCT00832130	Treatment of Meibomian Gland Dysfunction and Evaporative Dry Eye	https://ClinicalTrials.gov/show/NCT00832130	Completed	TearScience, Inc.	2009-06-30
NCT00831662	The Effects of Diquafosol Tetrasodium Ophthalmic Solution, 2% in Subjects With Dry Eye Disease (P08637)	https://ClinicalTrials.gov/show/NCT00831662	Completed	Merck Sharp & Dohme Corp.	2009-12-31
NCT04030962	A Study of the Drugs AGN-242428 and AGN-231868 in Participants With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT04030962	Recruiting	Allergan	2020-09-30
NCT03888183	Effect of Preservative-free Low-dose Hyaluronic Acid-containing Salt Solution on Dry Eye Disease	https://ClinicalTrials.gov/show/NCT03888183	Recruiting	Chang Gung Memorial Hospital	2020-01-22
NCT03788486	Efficacy and Safety of Meibomian Gland Dysfunction and Dry Eye With an LED Blue Treatment Device	https://ClinicalTrials.gov/show/NCT03788486	Recruiting	Toyos Clinic	2020-06-01
NCT03768115	Autologous Plasma Treatment for Severe Dry Eye Patients	https://ClinicalTrials.gov/show/NCT03768115	Recruiting	Singapore National Eye Centre	2023-12-31
NCT03322917	Ocular Surface Syndrome Post-lasik, Outcomes of Treatment With Platelet Rich Plasma	https://ClinicalTrials.gov/show/NCT03322917	Completed	Vissum, Instituto Oftalmológico de Alicante	2013-01-17
NCT00814944	A Dose-Ranging Clinical Study to Assess the Safety and Efficacy of Subconjunctival Injection of Sirolimus in Patients With Dry Eye in the Controlled Adverse Environmental (CAE) Model	https://ClinicalTrials.gov/show/NCT00814944	Completed	Santen Inc.	2009-10-31
NCT00814515	Double-Masked Trial of NOVA22007 (Ciclosporin 0.1%) Versus Vehicle in Patients With Moderate to Severe Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT00814515	Completed	Santen SAS	2009-09-30
NCT00809198	Kynex Versus Refresh Plus Study in Subject With Dry Eye	https://ClinicalTrials.gov/show/NCT00809198	Completed	Alcon Research	2009-05-31
NCT01933165	Reproducibility of LipiView Ocular Surface Interferometer (LipiView) for Measuring Tear Lipid Layer Thickness	https://ClinicalTrials.gov/show/NCT01933165	Completed	Singapore National Eye Centre	2014-02-28
NCT01718028	The Effect of SYSTANE® BALANCE on Tear Film Break Up Time in Dry Eye Subjects	https://ClinicalTrials.gov/show/NCT01718028	Completed	Alcon Research	2012-10-31
NCT00804791	Residence Time Evaluation of Marketed OTC Ophthalmic Products	https://ClinicalTrials.gov/show/NCT00804791	Completed	Alcon Research	2009-02-28
NCT00802399	Partial Lacrimal Punctual Occlusion	https://ClinicalTrials.gov/show/NCT00802399	Completed	University of Sao Paulo General Hospital	2008-11-30
NCT03451396	Effect of Lifitegrast on Dry Eye Disease Signs and Symptoms	https://ClinicalTrials.gov/show/NCT03451396	Completed	Lifelong Vision Foundation	2018-02-01
NCT03418259	Intra-Nasal Mechanical Stimulation (INMEST) as a Treatment of Keratoconjunctivitis Sicca (Dry Eye Syndrome)	https://ClinicalTrials.gov/show/NCT03418259	Recruiting	Karolinska Institutet	2021-12-31
NCT03162783	A Randomized, Double Masked, Clinical Study of Subjects With Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT03162783	Completed	Aldeyra Therapeutics, Inc.	2017-07-06
NCT03223909	Efficacy and Safety of the Ophthalmic Solution PRO-087 Versus Systane ® Ultra and Ultra Preservative Free (087LATAMFIV)	https://ClinicalTrials.gov/show/NCT03223909	Completed	Laboratorios Sophia S.A de C.V.	2018-10-16
NCT03089580	Intense Pulsed Light Study for Dry Eye Disease	https://ClinicalTrials.gov/show/NCT03089580	Completed	University of Michigan	2018-11-01
NCT03048526	Influence of Perfluorohexyloctane (NovaTears) on Tear Film Thickness in Patients With Mild to Moderate Dry Eye Disease	https://ClinicalTrials.gov/show/NCT03048526	Completed	Novaliq GmbH	2017-04-18
NCT02985827	Symptom Response in Normal and Dry Eye Patients Secondary to Application of a Menthol-Containing Eyedrop (Rohto® Hydra)	https://ClinicalTrials.gov/show/NCT02985827	Completed	ORA, Inc.	2016-01-31
NCT02798289	Acute Tear Production Following Single Use of the Oculeve Intranasal Neurostimulator	https://ClinicalTrials.gov/show/NCT02798289	Completed	Oculeve, Inc.	2016-08-31
NCT02066051	IPL and Meibomian Gland Expression to Treat Ocular Rosacea Ocular GVHD	https://ClinicalTrials.gov/show/NCT02066051	Completed	Mayo Clinic	2014-11-30
NCT01614847	Tear Osmolarity Changes After Instilling Isotonic Hyaluronate Artificial Tears	https://ClinicalTrials.gov/show/NCT01614847	Completed	Northeastern State University	2012-08-31
NCT04125134	Predicting the Success of Dry Eye Disease Interventions Using Clinical Tests	https://ClinicalTrials.gov/show/NCT04125134	Recruiting	Tufts Medical Center	2020-05-31
NCT03920215	Clinical Trial to Evaluate the Long Term Follow up of the Efficacy of OC-01 Nasal Spray on Signs and Symptoms of Dry Eye Disease (The ONSET Study)	https://ClinicalTrials.gov/show/NCT03920215	Completed	Oyster Point Pharma, Inc.	2019-10-12
NCT03676335	Assess the Safety and Efficacy of CsA Ophthalmic Gel in Subjects With Dry Eye	https://ClinicalTrials.gov/show/NCT03676335	Completed	Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.	2019-06-30
NCT01030237	An Evaluation of the Safety and Efficacy of FID 114657	https://ClinicalTrials.gov/show/NCT01030237	Completed	Alcon Research	2010-01-31
NCT00788229	Efficacy and Safety Study of ATs in Patients With Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT00788229	Completed	Dhp Korea Co., Ltd.	2009-08-31
NCT00784719	A Prospective, Randomized, Placebo and Active Comparator Controlled Study of CP-690,550 in Subjects With Dry Eye.	https://ClinicalTrials.gov/show/NCT00784719	Completed	Pfizer	2009-10-31
NCT00781092	A Prospective, Randomized, Double-Masked, Single Center, Clinical Comparison of the Use of Systane Ultra in the Management of Dry Eyes in Bilateral Eyes	https://ClinicalTrials.gov/show/NCT00781092	Completed	Durrie Vision	2009-03-31
NCT00779987	Autologous Serum Efficacy Study in Patients With Severe Dry Eye	https://ClinicalTrials.gov/show/NCT00779987	Completed	University of Chile	2008-12-31
NCT00765804	Safety and Efficacy Study of Iontophoresis and Dexamethasone Phosphate to Treat Dry Eye	https://ClinicalTrials.gov/show/NCT00765804	Completed	Eyegate Pharmaceuticals, Inc.	2009-02-28
NCT00761202	Performance and Acceptance of Optive Versus Hylocomod Eyedrops in Patients With Dry Eye Symptoms	https://ClinicalTrials.gov/show/NCT00761202	Completed	Allergan	2008-06-30
NCT00760045	Clinical Pharmacological Study of AL-43546 Ophthalmic Product in Subjects With Shortened Tear Film Break Up Time	https://ClinicalTrials.gov/show/NCT00760045	Completed	Alcon Research	2008-10-31
NCT00758784	Safety and Efficacy of an Ophthalmic Solution in Dry Eye Disease	https://ClinicalTrials.gov/show/NCT00758784	Completed	Bausch & Lomb Incorporated	2009-06-30
NCT00756678	Efficacy and Acceptability of Two Lubricant Eye Drops	https://ClinicalTrials.gov/show/NCT00756678	Completed	Allergan	2009-08-31
NCT00756093	Acute Comfort and Blurring Profile Evaluation of Marketed Lubricant Eye Drops	https://ClinicalTrials.gov/show/NCT00756093	Completed	Alcon Research	2008-09-30
NCT00748865	Acute Comfort and Blur of Systane Ultra and Systane	https://ClinicalTrials.gov/show/NCT00748865	Completed	Alcon Research	2008-08-31
NCT00743249	Punctal Plug Study to Determine the Safety and Retention Times of Various Lengths of Canalicular Stents in Volunteers	https://ClinicalTrials.gov/show/NCT00743249	Completed	Alcon Research	2009-02-28
NCT00739713	Effects of Sea Buckthorn Oil on Dry Eye	https://ClinicalTrials.gov/show/NCT00739713	Completed	University of Turku	2009-03-31
NCT00739349	NOVA22007 0.05% and 0.1% Cyclosporine Versus Vehicle for the Treatment of Dry Eye	https://ClinicalTrials.gov/show/NCT00739349	Completed	Santen SAS	2009-01-31
NCT00735865	Lid Margin And Conjunctival Microbial Flora Following Punctum Occlusion	https://ClinicalTrials.gov/show/NCT00735865	Completed	Lahey Clinic	2009-04-30
NCT00724412	Evaluate Artificial Tear Efficacy in Moderate to Severe Dry Eye	https://ClinicalTrials.gov/show/NCT00724412	Completed	Alcon Research	2009-02-28
NCT00721656	Phase 2 Study of KLS-0611 in Patients With Dry Eye Syndromes	https://ClinicalTrials.gov/show/NCT00721656	Completed	Kissei Pharmaceutical Co., Ltd.	NA
NCT00681265	Tear Film Break-up Time After Instillation of Artificial Tears	https://ClinicalTrials.gov/show/NCT00681265	Completed	Eyeon Therapeutics, Inc.	2008-08-31
NCT00680108	A Study to Determine the Safety and Tolerability of Escalating Doses of INS365 Ophthalmic Solution	https://ClinicalTrials.gov/show/NCT00680108	Completed	Merck Sharp & Dohme Corp.	2000-05-31
NCT00679718	A Study of INS365 Ophthalmic Solution in Patients With Moderate to Severe Dry Eye Disease	https://ClinicalTrials.gov/show/NCT00679718	Completed	Merck Sharp & Dohme Corp.	2000-07-31
NCT00673855	Acute Comfort of Lubricant Eye Drops FID 112903	https://ClinicalTrials.gov/show/NCT00673855	Completed	Alcon Research	2008-05-31
NCT00667004	Efficacy Study of Ecabet Ophthalmic Solution in Dry Eye Disease	https://ClinicalTrials.gov/show/NCT00667004	Completed	Bausch & Lomb Incorporated	2008-12-31
NCT00622037	Bilateral, Masked Comparison of PEG-400 Based Artificial Tear and Systane for the Treatment of Dry Eye Signs, Symptoms and Visual Quality	https://ClinicalTrials.gov/show/NCT00622037	Completed	Bp Consulting, Inc	2008-05-31
NCT00620893	Bilateral, Masked Comparison of PEG-400 Based Artificial Tear vs. Systane for Dry Eye Signs, Symptoms & Refractive Regression Associated With Myopic Laser in Situ Keratomilieusis (LASIK).	https://ClinicalTrials.gov/show/NCT00620893	Completed	Bp Consulting, Inc	2009-05-31
NCT00611403	Safety and Efficacy Study of Cyclosporine Ophthalmic Emulsion in Post-LASIK Patients	https://ClinicalTrials.gov/show/NCT00611403	Completed	Allergan	2008-12-31
NCT00610480	Effects of Tear Film Stability After Instillation Of OTC Artificial Drops	https://ClinicalTrials.gov/show/NCT00610480	Completed	University of Texas Southwestern Medical Center	2009-03-31
NCT00607776	Artificial Tears Study in Mild to Moderate Dry Eye Patients	https://ClinicalTrials.gov/show/NCT00607776	Completed	Abbott Medical Optics	NA
NCT00600288	Study of the Effect of Diquafosol Tetrasodium Ophthalmic Solution, 2% Versus Placebo in Dry Eye Subjects (P08634)	https://ClinicalTrials.gov/show/NCT00600288	Completed	Merck Sharp & Dohme Corp.	2008-05-31
NCT00599716	Safety and Efficacy Assessment of Vismed® (Sodium Hyaluronate) for the Treatment of Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT00599716	Completed	Lantibio	2008-04-30
NCT00568386	Acute Comfort and Blur of Systane and Optive	https://ClinicalTrials.gov/show/NCT00568386	Completed	Alcon Research	NA
NCT00567177	Objective Measurements of Prolonged Effects of Restasis on Dry Eye Disease	https://ClinicalTrials.gov/show/NCT00567177	Completed	Innovative Medical	NA
NCT00565669	Evaluation of Blink Tears and Systane Concomitant With Restasis for the Treatment of Dry Eye Symptoms	https://ClinicalTrials.gov/show/NCT00565669	Completed	Medical University of South Carolina	2008-10-31
NCT00560638	Loteprednol Etabonate Opthalmic Suspension for the Treatment of Dry Eye	https://ClinicalTrials.gov/show/NCT00560638	Completed	Bausch & Lomb Incorporated	2006-02-28
NCT00554879	Acupuncture Treatment of Dry Eye	https://ClinicalTrials.gov/show/NCT00554879	Completed	Walter Reed Army Medical Center	2011-02-28
NCT00549289	Study of Cyclosporine in the Treatment of Dry Eye Syndrome (ST-603-006)	https://ClinicalTrials.gov/show/NCT00549289	Completed	Sirion Therapeutics, Inc.	NA
NCT00548301	Study of Cyclosporine in the Treatment of Dry Eye Syndrome (ST-603-007)	https://ClinicalTrials.gov/show/NCT00548301	Completed	Sirion Therapeutics, Inc.	NA
NCT00544713	Evaluate the Safety and Efficacy of a New Artificial Tear for Use After LASIK Surgery	https://ClinicalTrials.gov/show/NCT00544713	Completed	Allergan	2008-06-30
NCT00535054	Study to Assess the Safety and Patients’ Satisfaction of Tears Again* in the Treatment of Dry Eye Symptoms	https://ClinicalTrials.gov/show/NCT00535054	Completed	Trima, Israel Pharmaceutical Products	2010-02-28
NCT00520260	Bromfenac 0.09% vs Ketorolac 0.4% for Cyclosporine Induction Phase	https://ClinicalTrials.gov/show/NCT00520260	Completed	Florida Eye Microsurgical Institute	2008-08-31
NCT00514852	Safety and Efficacy of an Artificial Tear for the Treatment of Dry Eye	https://ClinicalTrials.gov/show/NCT00514852	Completed	Allergan	2008-01-31
NCT00502073	Study of Cyclosporine in the Treatment of Dry Eye Syndrome (ST-603-005)	https://ClinicalTrials.gov/show/NCT00502073	Completed	Sirion Therapeutics, Inc.	NA
NCT00475319	Late Phase 2 Study of OPC-12759 Ophthalmic Suspension	https://ClinicalTrials.gov/show/NCT00475319	Completed	Otsuka Pharmaceutical Co., Ltd.	2008-03-31
NCT00471419	Phase II Study of AL-2178 (FID 109980) in the Treatment of Dry Eye	https://ClinicalTrials.gov/show/NCT00471419	Completed	Alcon Research	2007-08-31
NCT00469573	Safety and Efficacy of Optive in Contact Lens Wearers With Dry Eyes	https://ClinicalTrials.gov/show/NCT00469573	Completed	Innovative Medical	2008-03-31
NCT00469157	Refractive Surgery and Optive Compatibility Study	https://ClinicalTrials.gov/show/NCT00469157	Completed	Innovative Medical	2008-04-30
NCT00442273	Comparison of Autologous Serum and Umbilical Cord Serum Eyedrops for Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT00442273	Completed	Chonnam National University Hospital	NA
NCT00439400	A Study of ALTY-0501 for the Treatment of Dry Eye Administered 4 Times a Day for a 56 Day Period	https://ClinicalTrials.gov/show/NCT00439400	Completed	Alacrity Biosciences, Inc.	NA
NCT00426543	Effect of B-cell Depletion in Patients With Primary Sjögren’s Syndrome	https://ClinicalTrials.gov/show/NCT00426543	Completed	University of Copenhagen	2010-06-30
NCT00799682	Exploratory Study Comparing Signs and Symptoms in Patients With Ocular Hypertension or Glaucoma Using Xalatan R® or Travatan Z®	https://ClinicalTrials.gov/show/NCT00799682	Completed	Ophthalmic Consultants of Long Island	2011-01-31
NCT00799552	Safety and Efficacy Study of RX-10045 on the Signs and Symptoms of Dry Eye	https://ClinicalTrials.gov/show/NCT00799552	Completed	Resolvyx Pharmaceuticals, Inc	2009-05-31
NCT00407043	Multicenter, Randomized, Controlled Study of the Effect of Lotemax on Initiation of Dry Eye Treatment With Restasis	https://ClinicalTrials.gov/show/NCT00407043	Completed	Ophthalmic Consultants of Long Island	2007-09-30
NCT00405457	Efficacy and Safety of a New Multi-dose Lubricant Eye Drop Concomitant With Restasis® (Cyclosporine A) for the Treatment of Dry Eye Symptoms	https://ClinicalTrials.gov/show/NCT00405457	Completed	Innovative Medical	2008-01-31
NCT00404131	Study of INS365 Ophthalmic Solution in Subjects With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT00404131	Completed	Merck Sharp & Dohme Corp.	2001-12-31
NCT00403975	Study of Diquafosol Tetrasodium Ophthalmic Solution in Subjects With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT00403975	Completed	Merck Sharp & Dohme Corp.	2004-11-30
NCT00403715	Study of INS365 Ophthalmic Solution in Subjects With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT00403715	Completed	Merck Sharp & Dohme Corp.	2002-09-30
NCT00399230	A Comparison of Optive in Patients Previously Using Systane for the Treatment of Dry Eye	https://ClinicalTrials.gov/show/NCT00399230	Completed	Innovative Medical	NA
NCT00399061	Efficacy of Optive Versus Systane Concomitant With Restasis (Cyclosporine A) for the Treatment of Dry Eye Symptoms	https://ClinicalTrials.gov/show/NCT00399061	Completed	Innovative Medical	2008-09-30
NCT00395759	The Visual Effect of an Investigational Artificial Tear in the Tear Layer.	https://ClinicalTrials.gov/show/NCT00395759	Completed	Southern California College of Optometry	NA
NCT00388791	Comparison of Systane Free vs. Saline in the Treatment of Dry Eye	https://ClinicalTrials.gov/show/NCT00388791	Completed	Southern California College of Optometry	NA
NCT00386646	Comparative Study of 0.5% Carboxymethylcellulose With 0.005% Stabilized Oxychlorocomplex (PURITEâ„¢) Versus 0.5% Carboxymethylcellulose in the Treatment of Dry Eye	https://ClinicalTrials.gov/show/NCT00386646	Completed	Chulalongkorn University	NA
NCT00372034	The Effect of Punctal Plugs on Tear Volume and Osmolality	https://ClinicalTrials.gov/show/NCT00372034	Completed	The University of New South Wales	2007-03-31
NCT00370747	Efficacy and Safety Study for Ecabet Ophthalmic Solution for Treating Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT00370747	Completed	Bausch & Lomb Incorporated	2007-06-30
NCT00357201	Efficacy of T1675 Versus Placebo in Patients With Bilateral Treated Moderate Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT00357201	Completed	Laboratoires Thea	NA
NCT00349466	Safety and Efficacy Study of CF101 to Treat Keratoconjunctivitis Sicca	https://ClinicalTrials.gov/show/NCT00349466	Completed	Can-Fite BioPharma	2009-05-31
NCT00349440	Efficacy of Cyclosporine for the Prevention and Treatment of Dry Eye Symptoms Following LASIK or Photorefractive Keratectomy	https://ClinicalTrials.gov/show/NCT00349440	Completed	Innovative Medical	2008-09-30
NCT00345241	Effects of Systane Versus Saline in Maintaining Tear Film Stability at Determined Time Points	https://ClinicalTrials.gov/show/NCT00345241	Completed	University of Texas Southwestern Medical Center	2006-12-31
NCT00344721	A Placebo Controlled Double Masked Clinical Assessment Study of Essential Fatty Acid Supplement and Its Effect on Patients With Apparent Aqueous Deficient Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT00344721	Completed	University of Texas Southwestern Medical Center	2008-10-31
NCT00335114	Efficacy of Cyclosporine Ophthalmic Emulsion in the Treatment of Dry Eye Syndrome in Contact Lens Wearers	https://ClinicalTrials.gov/show/NCT00335114	Completed	University of Alabama at Birmingham	NA
NCT00284999	Soothe Versus Refresh	https://ClinicalTrials.gov/show/NCT00284999	Completed	Pharmaceutical Research Network	NA
NCT00234078	Dose-response Study of OPC-12759 Ophthalmic Suspension	https://ClinicalTrials.gov/show/NCT00234078	Completed	Otsuka Pharmaceutical Co., Ltd.	2006-04-30
NCT00201981	Study of Rebamipide Eye Drops to Treat Dry Eye	https://ClinicalTrials.gov/show/NCT00201981	Completed	Otsuka Pharmaceutical Development & Commercialization, Inc.	NA
NCT00201955	Study of Rebamipide Eye Drops to Treat Dry Eye	https://ClinicalTrials.gov/show/NCT00201955	Completed	Otsuka Pharmaceutical Development & Commercialization, Inc.	NA
NCT00198536	Efficacy and Safety Study for Ecabet Ophthalmic Solution for Treating Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT00198536	Completed	Bausch & Lomb Incorporated	2005-12-31
NCT00128245	Safety and Efficacy of Pimecrolimus Ophthalmic Suspension in Patients With Moderate to Severe Keratoconjunctivitis Sicca	https://ClinicalTrials.gov/show/NCT00128245	Completed	Novartis	2006-12-31
NCT00818909	Systane Clinical Experience Study	https://ClinicalTrials.gov/show/NCT00818909	Completed	Alcon Research	2009-10-31
NCT00001731	Treatment of Dry Eye Syndrome With Cyclosporin A Eye Drops	https://ClinicalTrials.gov/show/NCT00001731	Completed	National Institutes of Health Clinical Center (CC)	NA
NCT00037661	Study of INS365 Ophthalmic Solution in a Controlled Adverse Environment in Patients With Dry Eye	https://ClinicalTrials.gov/show/NCT00037661	Completed	Merck Sharp & Dohme Corp.	2003-03-31
NCT00818324	Long Term Administration Study of OPC-12759 Ophthalmic Suspension	https://ClinicalTrials.gov/show/NCT00818324	Completed	Otsuka Pharmaceutical Co., Ltd.	2010-09-30
NCT00025818	Six Month Clinical Research Study for Patients With Moderate or Severe Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT00025818	Completed	Allergan	2003-03-31
NCT00673959	Acute Comfort of Lubricant Eye Drop FID 111421	https://ClinicalTrials.gov/show/NCT00673959	Completed	Alcon Research	2008-02-29

Observational Studiess

#If less then 500 studies

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT04458012	Epidemiological Study of Dry Eye Disease in Stavanger: Dry Eye Disease in Patients Treated With Intravitreal Injections	https://ClinicalTrials.gov/show/NCT04458012	Enrolling by invitation	Helse Stavanger HF	2023-06-25
NCT03364322	Influencing Factors on Dry Eye Syndrome and Ocular Surface Disease	https://ClinicalTrials.gov/show/NCT03364322	Completed	Hallym University Kangnam Sacred Heart Hospital	2017-06-30
NCT03358979	Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALTESSE)	https://ClinicalTrials.gov/show/NCT03358979	Recruiting	Fondation Ophtalmologique Adolphe de Rothschild	2021-12-31
NCT03061578	Evaluation of Dry Eye by Tear Film Imager in a Low Humidity Environmental Exposure Chamber (TFI-LH16)	https://ClinicalTrials.gov/show/NCT03061578	Completed	Adom Advanced Optical Technologies Ltd.	2017-03-11
NCT02851654	Interest of Eye Movement Measurements in the Comprehension of Dry Eyes Symptoms	https://ClinicalTrials.gov/show/NCT02851654	Completed	Fondation Ophtalmologique Adolphe de Rothschild	2019-10-30
NCT02715323	Exploring Immune Cell Signatures in Autoimmunity and Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT02715323	Recruiting	Singapore National Eye Centre	2020-07-31
NCT02712762	Ocular Surface Disease in Chronic Graft-Versus-Host Disease (GVHD) Patients	https://ClinicalTrials.gov/show/NCT02712762	Recruiting	Singapore National Eye Centre	2020-11-30
NCT02645045	Evaluation of Factors Affecting the Tear-film Lipid Layer Thickness	https://ClinicalTrials.gov/show/NCT02645045	Completed	Yonsei University	2016-02-10
NCT02585414	Assessment of TFT by OCT in Healthy Subjects and Subjects With DES	https://ClinicalTrials.gov/show/NCT02585414	Recruiting	Medical University of Vienna	2020-01-31
NCT03399292	Effect of Lipid Based Eye Drops on Tear Film Lipid Layer Thickness	https://ClinicalTrials.gov/show/NCT03399292	Recruiting	Medical University of Vienna	2020-12-31
NCT02522312	A Retrospective Analysis of Restasis® Benefits in Dry Eye Contact Lens Patients	https://ClinicalTrials.gov/show/NCT02522312	Completed	Hazleton Eye Specialists	2015-12-31
NCT02376556	The Effect of Eyelid Surgery on Dry Eye - a Prospective Study	https://ClinicalTrials.gov/show/NCT02376556	Completed	Sheba Medical Center	2018-03-31
NCT02356341	NovaTears® Eye Drops Observational Study NT-002	https://ClinicalTrials.gov/show/NCT02356341	Completed	Novaliq GmbH	2015-12-31
NCT02356328	NovaTears® Eye Drops Observational Study NT-003	https://ClinicalTrials.gov/show/NCT02356328	Completed	Novaliq GmbH	2016-01-31
NCT02315079	Point of Care Testing of Inflammatory Markers in Tears	https://ClinicalTrials.gov/show/NCT02315079	Completed	University of Florida	2017-01-31
NCT02252744	Prevalence of Dry Eye Disease in Patients Diagnosed With Rheumatoid Arthritis	https://ClinicalTrials.gov/show/NCT02252744	Completed	Western University of Health Sciences	2014-06-30
NCT02161341	Ocular Surface Microbiome in Dry Eye Patients	https://ClinicalTrials.gov/show/NCT02161341	Completed	Singapore National Eye Centre	2018-10-31
NCT02111928	NovaTears® Eye Drops Observational Study	https://ClinicalTrials.gov/show/NCT02111928	Completed	Novaliq GmbH	2014-05-31
NCT02042820	Ocular Surface Immune Response in Dry Eye Disease	https://ClinicalTrials.gov/show/NCT02042820	Completed	Tufts Medical Center	2015-07-31
NCT01988597	Dry Eye Symptoms and Quality of Life	https://ClinicalTrials.gov/show/NCT01988597	Completed	Singapore National Eye Centre	2014-04-30
NCT01942226	Investigation on Medical Management of Dry Eye Patients	https://ClinicalTrials.gov/show/NCT01942226	Completed	National Cheng Kung University	2013-11-30
NCT01882413	A Study to Determine the Prevalence of Inflammatory Dry Eye Disease in Patients Prior to Cataract Removal	https://ClinicalTrials.gov/show/NCT01882413	Completed	Allergan	2014-03-31
NCT01854905	An Observational Study of Dry Eye Prior to Laser-Assisted in Situ Keratomileusis (LASIK) Therapy	https://ClinicalTrials.gov/show/NCT01854905	Completed	Allergan	2013-09-30
NCT01826812	Impairment of Reading Ability in Dry Eye Patients	https://ClinicalTrials.gov/show/NCT01826812	Completed	Johns Hopkins University	2015-11-30
NCT01711424	An Observational Study of OPTIVE PLUS® for the Treatment of Dry Eye Disease	https://ClinicalTrials.gov/show/NCT01711424	Completed	Allergan	2013-03-31
NCT01684852	Non Interventional Study to Evaluate the Efficacy and Tolerability of Ectoin Containing Ophthalmic Solution	https://ClinicalTrials.gov/show/NCT01684852	Completed	Bitop AG	2012-12-31
NCT01679015	Evaluating Patients With Eye Allergies and Determining if There Are Also Dry Eyes	https://ClinicalTrials.gov/show/NCT01679015	Completed	Schwartz Laser Eye Center	2014-02-28
NCT01611922	Optimization of Assessment and Grading for Lid Wiper Epitheliopathy	https://ClinicalTrials.gov/show/NCT01611922	Completed	Alcon Research	2012-05-31
NCT01547936	Effect of Controlled Adverse Environment (CAE) on Tear Film Stability	https://ClinicalTrials.gov/show/NCT01547936	Completed	ORA, Inc.	2012-02-29
NCT01507025	The Effect of Hinge Location on Corneal Sensation and Dry Eye After LASIK: A Systematic Review and Meta-analysis	https://ClinicalTrials.gov/show/NCT01507025	Completed	Wenzhou Medical University	2014-02-28
NCT01496482	Comparison of Evaporimetry With the Established Methods of Tear Film Measurement	https://ClinicalTrials.gov/show/NCT01496482	Completed	University of Zagreb	2009-02-28
NCT01321424	Diurnal Variation in Tear Osmolarity	https://ClinicalTrials.gov/show/NCT01321424	Completed	Ophthalmic Consultants of Long Island	2016-02-29
NCT04147962	Intense Pulsed Light in Meibomian Gland Dysfunctions	https://ClinicalTrials.gov/show/NCT04147962	Recruiting	Centre Hospitalier Universitaire de Saint Etienne	2020-10-31
NCT04043949	The Influences of Dry Eye Disease on Optical Quality	https://ClinicalTrials.gov/show/NCT04043949	Completed	Peking University Third Hospital	2018-07-01
NCT03938207	Taiwan Biobank Among Dry Eye Syndrome, Healthy Control in Taiwan	https://ClinicalTrials.gov/show/NCT03938207	Active, not recruiting	Taipei Veterans General Hospital, Taiwan	2019-05-01
NCT03866629	The Effect Of Lifitegrast On Refractive Accuracy And Symptoms In Dry Eye Patients Undergoing Cataract Surgery	https://ClinicalTrials.gov/show/NCT03866629	Completed	MDbackline, LLC	2019-10-29
NCT03753893	Ocular Manifestations in Rheumatic Diseases	https://ClinicalTrials.gov/show/NCT03753893	Active, not recruiting	Lawson Health Research Institute	2020-10-01
NCT01254201	The Pathogenesis of Idiopathic Dry Eyes	https://ClinicalTrials.gov/show/NCT01254201	Completed	University of Michigan	2015-12-31
NCT01206244	Diurnal Variation of Tear Meniscus and Tear Osmolarity	https://ClinicalTrials.gov/show/NCT01206244	Completed	University of Miami	2011-09-30
NCT01176045	TearLab Refractive Surgery Dry Eye Study	https://ClinicalTrials.gov/show/NCT01176045	Completed	TearLab Corporation	2011-12-31
NCT01161771	Effects of Cataract Extraction Surgery and Limbal Relaxing Incision on Corneal Sensation and Dry Eye	https://ClinicalTrials.gov/show/NCT01161771	Completed	Allergan	2010-12-31
NCT01016405	Prospective Health Assessment of Cataract Patients’ Ocular Surface	https://ClinicalTrials.gov/show/NCT01016405	Completed	Innovative Medical	2010-09-30
NCT01014780	Tear Film Thickness Measured Using a Novel Technique	https://ClinicalTrials.gov/show/NCT01014780	Completed	Southern California College of Optometry	2010-04-30
NCT00991679	CXCL9, CXCL10, CXCL11, and CXCR3 in Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT00991679	Completed	Chonnam National University Hospital	2008-10-31
NCT00893243	Efficacy Comparative Study Between Tears Again®, Opticol® and Optive®	https://ClinicalTrials.gov/show/NCT00893243	Completed	Hospital de Sao Sebastiao	NA
NCT00854906	Keratometric Tear Breakup Time and Fluorescein Tear Breakup Time	https://ClinicalTrials.gov/show/NCT00854906	Completed	University of Arkansas	2009-06-30
NCT00848198	TearLab Core Validation Study to Establish Referent Values for Dry Eye Disease	https://ClinicalTrials.gov/show/NCT00848198	Completed	TearLab Corporation	2011-03-31
NCT00833235	A Natural History Study of Patients With Dry Eye	https://ClinicalTrials.gov/show/NCT00833235	Completed	Allergan	2017-03-06
NCT00827255	Physician’s Evaluation of Cyclosporine Ophthalmic Emulsion 0.05%	https://ClinicalTrials.gov/show/NCT00827255	Completed	Allergan	2009-06-30
NCT00809003	Assessment of Inflammatory and Functional Changes in the Ocular Surface Associated With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT00809003	Completed	University of Waterloo	NA
NCT03937271	Objective Measurement Methods for Autoimmune Disease and Dry Eye Syndrome	https://ClinicalTrials.gov/show/NCT03937271	Active, not recruiting	Taipei Veterans General Hospital, Taiwan	2019-05-31
NCT03135327	Clinical Applications of Advanced Ophthalmic Imaging	https://ClinicalTrials.gov/show/NCT03135327	Recruiting	University of Miami	2020-12-31
NCT00761917	Diagnostic Evaluation of the Tear Film	https://ClinicalTrials.gov/show/NCT00761917	Completed	TearScience, Inc.	2008-10-31
NCT00731484	Validation of TearLab Osmometer - Human Factor Usability Report	https://ClinicalTrials.gov/show/NCT00731484	Completed	TearLab Corporation	2009-03-31
NCT00717418	Efficacy Study of Cyclosporine Ophthalmic Emulsion in Patients With Dry Eye Disease	https://ClinicalTrials.gov/show/NCT00717418	Completed	Allergan	2006-08-31
NCT00706940	Tear Dynamics After Restasis Treatment in Dry Eye Patients	https://ClinicalTrials.gov/show/NCT00706940	Completed	University of Miami	2016-12-31
NCT00553579	The Relationship of Residence Time and Visual Effect of Optive and Systane in Dry Eye Subjects	https://ClinicalTrials.gov/show/NCT00553579	Completed	Southern California College of Optometry	2008-05-31
NCT00522600	Eye Drop Use in Glaucoma Patients Through Patient Surveys and Video Observations	https://ClinicalTrials.gov/show/NCT00522600	Completed	Robin, Alan L., M.D.	NA
NCT00769665	A 2-week Clinical Comparison of SYSTANE® Ultra to Sensitive Eyes Rewetting Drops in Contact Lens Wearing Patients.	https://ClinicalTrials.gov/show/NCT00769665	Completed	Alcon Research	2009-01-31

Registries

#If less then 500 registries

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT02011776	A Randomized, Parallel-Group Comparison Study of Topical Corticosteroids in Dry Eye Patients With Sjögren Syndrome	https://ClinicalTrials.gov/show/NCT02011776	Completed	Santen Pharmaceutical(China) Co.,LTD	2013-08-31
NCT04413370	Dry Eye Screening and Referral System	https://ClinicalTrials.gov/show/NCT04413370	Recruiting	Sun Yat-sen University	2020-08-06
NCT04109170	Dry Eye Evaluation System Based on Bioinformatics	https://ClinicalTrials.gov/show/NCT04109170	Recruiting	Huaxia Eye Hospital Group	2019-12-23
NCT03731624	Diadenosine Polyphosphates and Mucin Associated With Ocular Surface Disorders	https://ClinicalTrials.gov/show/NCT03731624	Recruiting	Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation	2020-12-31
NCT03652415	DRy Eye Outcome and Prescription Study	https://ClinicalTrials.gov/show/NCT03652415	Recruiting	Guy’s and St Thomas’ NHS Foundation Trust	2021-08-23